New Horizons in Hydrogels for Methotrexate Delivery

Ali Dehshahri, Anuj Kumar, Vijay Sagar Madamsetty, Ilona Uzieliene, Shima Tavakol, Fereshteh Azedi, Hojjat Samareh Fekri, Ali Zarrabi, Reza Mohammadinejad, Vijay Kumar Thakur

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)
68 Downloads (Pure)


Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led researchers to seek novel delivery systems to improve its characteristics for parenteral and oral administration. Recently, great attention has been directed to hydrogels for the preparation of MTX formulations. This review describes the potential of hydrogels for the formulation of MTX to treat cancer, rheumatoid arthritis, psoriasis and central nervous system diseases. We will delineate the state-of-the-art and promising potential of hydrogels for systemic MTX delivery as well as transdermal delivery of the drug-using hydrogel-based formulations.

Original languageEnglish
Article number2
Number of pages20
Issue number1
Early online date30 Dec 2020
Publication statusFirst published - 30 Dec 2020


  • Cancer
  • Drug delivery
  • Hydrogels
  • Methotrexate
  • Psoriasis
  • Rheumatoid arthritis


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