New Horizons in Hydrogels for Methotrexate Delivery

Ali Dehshahri; Anuj Kumar; Vijay Sagar Madamsetty; Ilona Uzieliene; Shima Tavakol; Fereshteh Azedi; Hojjat Samareh Fekri; Ali Zarrabi; Reza Mohammadinejad; Vijay Kumar Thakur

doi:10.3390/gels7010002

New Horizons in Hydrogels for Methotrexate Delivery

Ali Dehshahri
, Anuj Kumar
, Vijay Sagar Madamsetty
, Ilona Uzieliene
, Shima Tavakol
, Fereshteh Azedi
, Hojjat Samareh Fekri
, Ali Zarrabi
, Reza Mohammadinejad
, Vijay Kumar Thakur

Biorefining And Advanced Materials Research Centre

Research output: Contribution to journal › Review article › peer-review

33 Citations (Scopus)

121 Downloads (Pure)

Abstract

Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led researchers to seek novel delivery systems to improve its characteristics for parenteral and oral administration. Recently, great attention has been directed to hydrogels for the preparation of MTX formulations. This review describes the potential of hydrogels for the formulation of MTX to treat cancer, rheumatoid arthritis, psoriasis and central nervous system diseases. We will delineate the state-of-the-art and promising potential of hydrogels for systemic MTX delivery as well as transdermal delivery of the drug-using hydrogel-based formulations.

Original language	English
Article number	2
Number of pages	20
Journal	Gels
Volume	7
Issue number	1
Early online date	30 Dec 2020
DOIs	https://doi.org/10.3390/gels7010002
Publication status	First published - 30 Dec 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer
Drug delivery
Hydrogels
Methotrexate
Psoriasis
Rheumatoid arthritis

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10.3390/gels7010002

gels-07-00002Final published version, 1.97 MBLicence: CC BY

Cite this

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title = "New Horizons in Hydrogels for Methotrexate Delivery",

abstract = "Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led researchers to seek novel delivery systems to improve its characteristics for parenteral and oral administration. Recently, great attention has been directed to hydrogels for the preparation of MTX formulations. This review describes the potential of hydrogels for the formulation of MTX to treat cancer, rheumatoid arthritis, psoriasis and central nervous system diseases. We will delineate the state-of-the-art and promising potential of hydrogels for systemic MTX delivery as well as transdermal delivery of the drug-using hydrogel-based formulations.",

keywords = "Cancer, Drug delivery, Hydrogels, Methotrexate, Psoriasis, Rheumatoid arthritis",

author = "Ali Dehshahri and Anuj Kumar and Madamsetty, \{Vijay Sagar\} and Ilona Uzieliene and Shima Tavakol and Fereshteh Azedi and Fekri, \{Hojjat Samareh\} and Ali Zarrabi and Reza Mohammadinejad and Thakur, \{Vijay Kumar\}",

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doi = "10.3390/gels7010002",

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T1 - New Horizons in Hydrogels for Methotrexate Delivery

AU - Dehshahri, Ali

AU - Kumar, Anuj

AU - Madamsetty, Vijay Sagar

AU - Uzieliene, Ilona

AU - Tavakol, Shima

AU - Azedi, Fereshteh

AU - Fekri, Hojjat Samareh

AU - Zarrabi, Ali

AU - Mohammadinejad, Reza

AU - Thakur, Vijay Kumar

PY - 2020/12/30

Y1 - 2020/12/30

N2 - Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led researchers to seek novel delivery systems to improve its characteristics for parenteral and oral administration. Recently, great attention has been directed to hydrogels for the preparation of MTX formulations. This review describes the potential of hydrogels for the formulation of MTX to treat cancer, rheumatoid arthritis, psoriasis and central nervous system diseases. We will delineate the state-of-the-art and promising potential of hydrogels for systemic MTX delivery as well as transdermal delivery of the drug-using hydrogel-based formulations.

AB - Since its first clinical application, methotrexate (MTX) has been widely used for the treatment of human diseases. Despite great advantages, some properties such as poor absorption, short plasma half-life and unpredictable bioavailability have led researchers to seek novel delivery systems to improve its characteristics for parenteral and oral administration. Recently, great attention has been directed to hydrogels for the preparation of MTX formulations. This review describes the potential of hydrogels for the formulation of MTX to treat cancer, rheumatoid arthritis, psoriasis and central nervous system diseases. We will delineate the state-of-the-art and promising potential of hydrogels for systemic MTX delivery as well as transdermal delivery of the drug-using hydrogel-based formulations.

KW - Cancer

KW - Drug delivery

KW - Hydrogels

KW - Methotrexate

KW - Psoriasis

KW - Rheumatoid arthritis

UR - https://www.scopus.com/pages/publications/85099984804

U2 - 10.3390/gels7010002

DO - 10.3390/gels7010002

M3 - Review article

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SN - 2310-2861

VL - 7

JO - Gels

JF - Gels

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ER -

New Horizons in Hydrogels for Methotrexate Delivery

Abstract

UN SDGs

Keywords

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