Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

Vijay Sagar Madamsetty, Maryam Vazifehdoost, Samira Hossaini Alhashemi, Hesam Davoudi, Ali Zarrabi, Ali Dehshahri, Hojjat Samareh Fekri, Reza Mohammadinejad, Vijay Kumar Thakur*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)
116 Downloads (Pure)


Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.
Original languageEnglish
Pages (from-to)8960-8976
Number of pages17
JournalACS Omega
Issue number10
Early online date28 Feb 2023
Publication statusPrint publication - 14 Mar 2023


  • General Chemical Engineering
  • General Chemistry


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