Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

Vijay Sagar Madamsetty; Maryam Vazifehdoost; Samira Hossaini Alhashemi; Hesam Davoudi; Ali Zarrabi; Ali Dehshahri; Hojjat Samareh Fekri; Reza Mohammadinejad; Vijay Kumar Thakur

doi:10.1021/acsomega.2c07062

Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

Vijay Sagar Madamsetty
, Maryam Vazifehdoost
, Samira Hossaini Alhashemi
, Hesam Davoudi
, Ali Zarrabi
, Ali Dehshahri
, Hojjat Samareh Fekri
, Reza Mohammadinejad
, Vijay Kumar Thakur^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

37 Citations (Scopus)

194 Downloads (Pure)

Abstract

Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.

Original language	English
Pages (from-to)	8960-8976
Number of pages	17
Journal	ACS Omega
Volume	8
Issue number	10
Early online date	28 Feb 2023
DOIs	https://doi.org/10.1021/acsomega.2c07062
Publication status	Print publication - 14 Mar 2023

Keywords

General Chemical Engineering
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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acsomega.2c07062Final published version, 11.8 MBLicence: CC BY

Cite this

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title = "Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin",

abstract = "Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.",

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doi = "10.1021/acsomega.2c07062",

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T1 - Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

AU - Madamsetty, Vijay Sagar

AU - Vazifehdoost, Maryam

AU - Alhashemi, Samira Hossaini

AU - Davoudi, Hesam

AU - Zarrabi, Ali

AU - Dehshahri, Ali

AU - Fekri, Hojjat Samareh

AU - Mohammadinejad, Reza

AU - Thakur, Vijay Kumar

PY - 2023/3/14

Y1 - 2023/3/14

N2 - Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.

AB - Since the first report on the pharmacological activity of curcumin in 1949, enormous amounts of research have reported diverse activities for this natural polyphenol found in the dietary spice turmeric. However, curcumin has not yet been used for human application as an approved drug. The clinical translation of curcumin has been hampered due to its low solubility and bioavailability. The improvement in bioavailability and solubility of curcumin can be achieved by its formulation using drug delivery systems. Hydrogels with their biocompatibility and low toxicity effects have shown a substantial impact on the successful formulation of hydrophobic drugs for human clinical trials. This review focuses on hydrogel-based delivery systems for curcumin and describes its applications as anti-cancer as well as wound healing agents.

KW - General Chemical Engineering

KW - General Chemistry

UR - https://www.scopus.com/pages/publications/85149139760

U2 - 10.1021/acsomega.2c07062

DO - 10.1021/acsomega.2c07062

M3 - Review article

C2 - 36936324

SN - 2470-1343

VL - 8

SP - 8960

EP - 8976

JO - ACS Omega

JF - ACS Omega

IS - 10

ER -

Next-Generation Hydrogels as Biomaterials for Biomedical Applications: Exploring the Role of Curcumin

Abstract

Keywords

UN SDGs

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