Novel Biocompatible Green Silver Nanoparticles Efficiently Eliminates Multidrug Resistant Nosocomial Pathogens and Mycobacterium Species

Shahbaz Aman, Narinder Kaur*, Divya Mittal, Deepanjali Sharma, Komal Shukla, Bharat Singh, Anchita Sharma, Samarjeet Singh Siwal, Vijay Kumar Thakur, Hemant Joshi, Raju Gupta*, Reena V. Saini*, Adesh K. Saini*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Bacterial infection is a major crisis of 21st era and the emergence of multidrug resistant (MDR) pathogens cause significant health problems. We developed, green chemistry-based silver nanoparticles (G-Ag NPs) using Citrus pseudolimon fruit peel extract. G-Ag NPs has a spherical shape in the range of ~ 40 nm with a surface charge of − 31 Mv. This nano-bioagent is an eco-friendly tool to combat menace of MDR. Biochemical tests prove that G-Ag NPs are compatible with human red blood cells and peripheral blood mononuclear cells. There have been many reports on the synthesis of silver nanoparticles, but this study suggests a green technique for making non-cytotoxic, non-hemolytic organometallic silver nanoparticles with a high therapeutic index for possible use in the medical field. On the same line, G-Ag NPs are very effective against Mycobacterium sp. and MDR strains including Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, and Acinetobacter baumannii isolated from patient samples. Based on it, we filed a patent to Indian Patent Office (reference no. 202111048797) which can revolutionize the prevention of biomedical device borne infections in hospital pre/post-operated cases. This work could be further explored in future by in vivo experimentation with mice model to direct its possible clinical utility.

Original languageEnglish
JournalIndian Journal of Microbiology
Early online date6 Feb 2023
DOIs
Publication statusFirst published - 6 Feb 2023

Bibliographical note

Funding Information:
No financial support was obtained from funding agencies in the public, commercial, or not-for-profit sectors.

Publisher Copyright:
© 2023, Association of Microbiologists of India.

Keywords

  • Biocompatible
  • Biogenic
  • Eco-friendly
  • Human pathogen
  • Multidrug-resistance
  • Silver nanoparticles

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