Novel Biocompatible Green Silver Nanoparticles Efficiently Eliminates Multidrug Resistant Nosocomial Pathogens and Mycobacterium Species

Shahbaz Aman, Narinder Kaur*, Divya Mittal, Deepanjali Sharma, Komal Shukla, Bharat Singh, Anchita Sharma, Samarjeet Singh Siwal, Vijay Kumar Thakur, Hemant Joshi, Raju Gupta*, Reena V. Saini*, Adesh K. Saini*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Bacterial infection is a major crisis of 21st era and the emergence of multidrug resistant (MDR) pathogens cause significant health problems. We developed, green chemistry-based silver nanoparticles (G-Ag NPs) using Citrus pseudolimon fruit peel extract. G-Ag NPs has a spherical shape in the range of ~ 40 nm with a surface charge of − 31 Mv. This nano-bioagent is an eco-friendly tool to combat menace of MDR. Biochemical tests prove that G-Ag NPs are compatible with human red blood cells and peripheral blood mononuclear cells. There have been many reports on the synthesis of silver nanoparticles, but this study suggests a green technique for making non-cytotoxic, non-hemolytic organometallic silver nanoparticles with a high therapeutic index for possible use in the medical field. On the same line, G-Ag NPs are very effective against Mycobacterium sp. and MDR strains including Escherichia coli, Klebsiella species, Pseudomonas aeruginosa, and Acinetobacter baumannii isolated from patient samples. Based on it, we filed a patent to Indian Patent Office (reference no. 202111048797) which can revolutionize the prevention of biomedical device borne infections in hospital pre/post-operated cases. This work could be further explored in future by in vivo experimentation with mice model to direct its possible clinical utility.

Original languageEnglish
Pages (from-to)73-83
Number of pages11
JournalIndian Journal of Microbiology
Volume63
Issue number1
Early online date6 Feb 2023
DOIs
Publication statusPrint publication - Mar 2023

Bibliographical note

© Association of Microbiologists of India 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Keywords

  • Biocompatible
  • Biogenic
  • Eco-friendly
  • Human pathogen
  • Multidrug-resistance
  • Silver nanoparticles

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