Materials and Methods: During the inaugural PGH workshop in East Africa, samples from Ugandan municipal sewage facilities were collected and two novel Escherichia coli lytic phages were isolated and characterized.
Results: The phages, UP19 (capsid diameter ∼100 nm, contractile tail ∼120/20 nm) and UP30 (capsid diameter ∼70 nm, noncontractile tail of ∼170/20 nm), lysed ∼82% and ∼36% of the 11 clinical isolates examined, respectively. The genomes of UP19 (171.402 kb, 282 CDS) and UP30 (49.834 kb, 75 CDS) closely match the genera Dhakavirus and Tunavirus, respectively.
Conclusion: The phages isolated have therapeutic potential for further development against E. coli infections.
Bibliographical noteCopyright 2023, Mary Ann Liebert, Inc., publishers.
- Phages for global health
- phage therapy
- Escherichia coli phage
- antimicrobial resistance
- Phages for Global Health