Novel picornavirus in lambs with severe encephalomyelitis

Leonie F Forth; Sandra F E Scholes; Patricia A Pesavento; Kenneth Jackson; Adrienne Mackintosh; Amanda Carson; Fiona Howie; Kore Schlottau; Kerstin Wernike; Anne Pohlmann; Dirk Höper; Martin Beer

doi:10.3201/eid2505.181573

Novel picornavirus in lambs with severe encephalomyelitis

Leonie F Forth, Sandra F E Scholes, Patricia A Pesavento, Kenneth Jackson, Adrienne Mackintosh, Amanda Carson, Fiona Howie, Kore Schlottau, Kerstin Wernike, Anne Pohlmann, Dirk Höper, Martin Beer^*

^*Corresponding author for this work

Veterinary Services

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Abstract

Using metagenomic analysis, we identified a novel picornavirus in young preweaned lambs with neurologic signs associated with severe nonsuppurative encephalitis and sensory ganglionitis in 2016 and 2017 in the United Kingdom. In situ hybridization demonstrated intralesional neuronotropism of this virus, which was also detected in archived samples of similarly affected lambs (1998-2014).

Original language	English
Pages (from-to)	963-967
Number of pages	5
Journal	Emerging Infectious Diseases
Volume	25
Issue number	5
Early online date	18 Apr 2019
DOIs	https://doi.org/10.3201/eid2505.181573
Publication status	Print publication - May 2019

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title = "Novel picornavirus in lambs with severe encephalomyelitis",

abstract = "Using metagenomic analysis, we identified a novel picornavirus in young preweaned lambs with neurologic signs associated with severe nonsuppurative encephalitis and sensory ganglionitis in 2016 and 2017 in the United Kingdom. In situ hybridization demonstrated intralesional neuronotropism of this virus, which was also detected in archived samples of similarly affected lambs (1998-2014).",

author = "Forth, {Leonie F} and Scholes, {Sandra F E} and Pesavento, {Patricia A} and Kenneth Jackson and Adrienne Mackintosh and Amanda Carson and Fiona Howie and Kore Schlottau and Kerstin Wernike and Anne Pohlmann and Dirk H{\"o}per and Martin Beer",

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AU - Forth, Leonie F

AU - Scholes, Sandra F E

AU - Pesavento, Patricia A

AU - Jackson, Kenneth

AU - Mackintosh, Adrienne

AU - Carson, Amanda

AU - Howie, Fiona

AU - Schlottau, Kore

AU - Wernike, Kerstin

AU - Pohlmann, Anne

AU - Höper, Dirk

AU - Beer, Martin

PY - 2019/5

Y1 - 2019/5

N2 - Using metagenomic analysis, we identified a novel picornavirus in young preweaned lambs with neurologic signs associated with severe nonsuppurative encephalitis and sensory ganglionitis in 2016 and 2017 in the United Kingdom. In situ hybridization demonstrated intralesional neuronotropism of this virus, which was also detected in archived samples of similarly affected lambs (1998-2014).

AB - Using metagenomic analysis, we identified a novel picornavirus in young preweaned lambs with neurologic signs associated with severe nonsuppurative encephalitis and sensory ganglionitis in 2016 and 2017 in the United Kingdom. In situ hybridization demonstrated intralesional neuronotropism of this virus, which was also detected in archived samples of similarly affected lambs (1998-2014).

U2 - 10.3201/eid2505.181573

DO - 10.3201/eid2505.181573

M3 - Article

C2 - 31002069

SN - 1080-6040

VL - 25

SP - 963

EP - 967

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

IS - 5

ER -

Novel picornavirus in lambs with severe encephalomyelitis

Abstract

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