Pathogenic potential to humans of Bovine Escherichia coli O26, Scotland

ME Chase-Topping, T Rosser, LJ Allison, E Courcier, J Evans, IJ McKendrick, MC Pearce, I Handel, A Caprioli, H Karch, MF Hanson, KGJ Pollock, ME Locking, MEJ Woolhouse, L Matthews, JC Low, DL Gally

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confi rmed the role of stx2 in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26–associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx2 phage acquisition.
Original languageEnglish
Pages (from-to)439 - 448
Number of pages10
JournalEmerging Infectious Diseases
Volume18(3)
Publication statusFirst published - 2012

Fingerprint

Scotland
Escherichia coli O157
Escherichia coli
Escherichia coli Infections
Hemolytic-Uremic Syndrome
Enterohemorrhagic Escherichia coli
Bacteriophages
Infection

Bibliographical note

560801

Keywords

  • Cattle
  • Escherichia coli
  • Infection
  • Pathogen
  • Scotland

Cite this

Chase-Topping, ME., Rosser, T., Allison, LJ., Courcier, E., Evans, J., McKendrick, IJ., ... Gally, DL. (2012). Pathogenic potential to humans of Bovine Escherichia coli O26, Scotland. Emerging Infectious Diseases, 18(3), 439 - 448.
Chase-Topping, ME ; Rosser, T ; Allison, LJ ; Courcier, E ; Evans, J ; McKendrick, IJ ; Pearce, MC ; Handel, I ; Caprioli, A ; Karch, H ; Hanson, MF ; Pollock, KGJ ; Locking, ME ; Woolhouse, MEJ ; Matthews, L ; Low, JC ; Gally, DL. / Pathogenic potential to humans of Bovine Escherichia coli O26, Scotland. In: Emerging Infectious Diseases. 2012 ; Vol. 18(3). pp. 439 - 448.
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Chase-Topping, ME, Rosser, T, Allison, LJ, Courcier, E, Evans, J, McKendrick, IJ, Pearce, MC, Handel, I, Caprioli, A, Karch, H, Hanson, MF, Pollock, KGJ, Locking, ME, Woolhouse, MEJ, Matthews, L, Low, JC & Gally, DL 2012, 'Pathogenic potential to humans of Bovine Escherichia coli O26, Scotland', Emerging Infectious Diseases, vol. 18(3), pp. 439 - 448.

Pathogenic potential to humans of Bovine Escherichia coli O26, Scotland. / Chase-Topping, ME; Rosser, T; Allison, LJ; Courcier, E; Evans, J; McKendrick, IJ; Pearce, MC; Handel, I; Caprioli, A; Karch, H; Hanson, MF; Pollock, KGJ; Locking, ME; Woolhouse, MEJ; Matthews, L; Low, JC; Gally, DL.

In: Emerging Infectious Diseases, Vol. 18(3), 2012, p. 439 - 448.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pathogenic potential to humans of Bovine Escherichia coli O26, Scotland

AU - Chase-Topping, ME

AU - Rosser, T

AU - Allison, LJ

AU - Courcier, E

AU - Evans, J

AU - McKendrick, IJ

AU - Pearce, MC

AU - Handel, I

AU - Caprioli, A

AU - Karch, H

AU - Hanson, MF

AU - Pollock, KGJ

AU - Locking, ME

AU - Woolhouse, MEJ

AU - Matthews, L

AU - Low, JC

AU - Gally, DL

N1 - 560801

PY - 2012

Y1 - 2012

N2 - Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confi rmed the role of stx2 in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26–associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx2 phage acquisition.

AB - Escherichia coli O26 and O157 have similar overall prevalences in cattle in Scotland, but in humans, Shiga toxin–producing E. coli O26 infections are fewer and clinically less severe than E. coli O157 infections. To investigate this discrepancy, we genotyped E. coli O26 isolates from cattle and humans in Scotland and continental Europe. The genetic background of some strains from Scotland was closely related to that of strains causing severe infections in Europe. Nonmetric multidimensional scaling found an association between hemolytic uremic syndrome (HUS) and multilocus sequence type 21 strains and confi rmed the role of stx2 in severe human disease. Although the prevalences of E. coli O26 and O157 on cattle farms in Scotland are equivalent, prevalence of more virulent strains is low, reducing human infection risk. However, new data on E. coli O26–associated HUS in humans highlight the need for surveillance of non-O157 enterohemorrhagic E. coli and for understanding stx2 phage acquisition.

KW - Cattle

KW - Escherichia coli

KW - Infection

KW - Pathogen

KW - Scotland

M3 - Article

VL - 18(3)

SP - 439

EP - 448

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

ER -

Chase-Topping ME, Rosser T, Allison LJ, Courcier E, Evans J, McKendrick IJ et al. Pathogenic potential to humans of Bovine Escherichia coli O26, Scotland. Emerging Infectious Diseases. 2012;18(3):439 - 448.