Phytochemicals as potent modulators of autophagy for cancer therapy

Mohammad Amin Moosavi*, Atousa Haghi, Marveh Rahmati, Hiroaki Taniguchi, Andrei Mocan, Javier Echeverría, Vijai K. Gupta, Nikolay T. Tzvetkov, Atanas G. Atanasov

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy.

Original languageEnglish
Pages (from-to)46-69
Number of pages24
JournalCancer Letters
Volume424
Early online date21 Feb 2018
DOIs
Publication statusPrint publication - 28 Jun 2018
Externally publishedYes

Keywords

  • Autophagy
  • Cancer
  • Cell death
  • Oxidative stress
  • Phytochemical
  • Therapy

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