Phytochemicals as potent modulators of autophagy for cancer therapy

Mohammad Amin Moosavi; Atousa Haghi; Marveh Rahmati; Hiroaki Taniguchi; Andrei Mocan; Javier Echeverría; Vijai K. Gupta; Nikolay T. Tzvetkov; Atanas G. Atanasov

doi:10.1016/j.canlet.2018.02.030

Phytochemicals as potent modulators of autophagy for cancer therapy

Mohammad Amin Moosavi^*, Atousa Haghi, Marveh Rahmati, Hiroaki Taniguchi, Andrei Mocan, Javier Echeverría, Vijai K. Gupta, Nikolay T. Tzvetkov, Atanas G. Atanasov

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy.

Original language	English
Pages (from-to)	46-69
Number of pages	24
Journal	Cancer Letters
Volume	424
Early online date	21 Feb 2018
DOIs	https://doi.org/10.1016/j.canlet.2018.02.030
Publication status	Print publication - 28 Jun 2018
Externally published	Yes

Keywords

Autophagy
Cancer
Cell death
Oxidative stress
Phytochemical
Therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2018.02.030

Cite this

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title = "Phytochemicals as potent modulators of autophagy for cancer therapy",

abstract = "The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy.",

keywords = "Autophagy, Cancer, Cell death, Oxidative stress, Phytochemical, Therapy",

author = "Moosavi, {Mohammad Amin} and Atousa Haghi and Marveh Rahmati and Hiroaki Taniguchi and Andrei Mocan and Javier Echeverr{\'i}a and Gupta, {Vijai K.} and Tzvetkov, {Nikolay T.} and Atanasov, {Atanas G.}",

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doi = "10.1016/j.canlet.2018.02.030",

language = "English",

volume = "424",

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journal = "Cancer Letters",

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TY - JOUR

T1 - Phytochemicals as potent modulators of autophagy for cancer therapy

AU - Moosavi, Mohammad Amin

AU - Haghi, Atousa

AU - Rahmati, Marveh

AU - Taniguchi, Hiroaki

AU - Mocan, Andrei

AU - Echeverría, Javier

AU - Gupta, Vijai K.

AU - Tzvetkov, Nikolay T.

AU - Atanasov, Atanas G.

PY - 2018/6/28

Y1 - 2018/6/28

N2 - The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy.

AB - The dysregulation of autophagy is involved in the pathogenesis of a broad range of diseases, and accordingly universal research efforts have focused on exploring novel compounds with autophagy-modulating properties. While a number of synthetic autophagy modulators have been identified as promising cancer therapy candidates, autophagy-modulating phytochemicals have also attracted attention as potential treatments with minimal side effects. In this review, we firstly highlight the importance of autophagy and its relevance in the pathogenesis and treatment of cancer. Subsequently, we present the data on common phytochemicals and their mechanism of action as autophagy modulators. Finally, we discuss the challenges associated with harnessing the autophagic potential of phytochemicals for cancer therapy.

KW - Autophagy

KW - Cancer

KW - Cell death

KW - Oxidative stress

KW - Phytochemical

KW - Therapy

UR - http://www.scopus.com/inward/record.url?scp=85044640907&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2018.02.030

DO - 10.1016/j.canlet.2018.02.030

M3 - Article

C2 - 29474859

AN - SCOPUS:85044640907

SN - 0304-3835

VL - 424

SP - 46

EP - 69

JO - Cancer Letters

JF - Cancer Letters

ER -

Phytochemicals as potent modulators of autophagy for cancer therapy

Abstract

Keywords

UN SDGs

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