Polymorphisms in MC1R and ASIP Genes are Associated with Coat Color Variation in the Arabian Camel

F. Almathen, H. Elbir, H. Bahbahani, J. Mwacharo, O. Hanotte

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Pigmentation in mammals is primarily determined by the distribution of eumelanin and pheomelanin, the ratio of which is mostly controlled by the activity of melanocortin 1 receptor (MC1R) and agouti signaling protein (ASIP) genes. Using 91 animals from 10 Arabian camel populations, that included the 4 predominant coat color phenotypes observed in the dromedary (light brown, dark brown, black, and white), we investigated the effects of the MC1R and ASIP sequence variants and identified candidate polymorphisms associated with coat color variation. In particular, we identified a single nucleotide polymorphism (SNP), found in the coding region of MC1R (901C/T), linked to the white coat color, whereas a 1-bp deletion (23delT/T) and a SNP (25G/A) in exon 2 of ASIP are associated with both black and dark-brown coat colors. Our results also indicate support that the light-brown coat color is likely the ancestral coat color for the dromedary. These sequence variations at the MC1R and ASIP genes represent the first documented evidence of candidate polymorphisms associated with Mendelian traits in the dromedary.
Original languageEnglish
Pages (from-to)700-706
Number of pages7
JournalJournal of Heredity
Volume109
Issue number6
Early online date9 Jun 2018
DOIs
Publication statusPrint publication - 2018
Externally publishedYes

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