Polysaccharide-based hydrogels: New insights and futuristic prospects in wound healing

Neha Raina, Rakesh Pahwa, Vijay Kumar Thakur*, Madhu Gupta*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)

Abstract

Polysaccharides elicit enormous and promising applications due to their extensive obtainability, innocuousness, and biodegradability. Various outstanding features of polysaccharides can be employed to fabricate biomimetic and multifunctional hydrogels as efficient wound dressings. These hydrogels mimic the natural extracellular matrix and also boost the proliferation of cells. Owing to distinctive architectures and abundance of functional groups, polysaccharide-derived hydrogels have exceptional physicochemical properties and unique therapeutic interventions. Hydrogels designed using polysaccharides can effectively safeguard wounds from bacterial attack. This review includes wound physiology and emphasises on numerous polysaccharide-based hydrogels for wound repair applications. Polysaccharide hydrogels for different wound types and diverse therapeutic agents loaded in hydrogels for wound repair with recent patents are portrayed in the current manuscript, debating the potential of fascinating hydrogels for effective wound healing. More research is required to engineer multifaceted advanced polysaccharide hydrogels with tuneable and adjustable properties to attain huge potential in wound healing.

Original languageEnglish
Pages (from-to)1586-1603
Number of pages18
JournalInternational Journal of Biological Macromolecules
Volume223
Issue numberPart A
Early online date14 Nov 2022
DOIs
Publication statusPrint publication - 31 Dec 2022

Bibliographical note

Publisher Copyright: © 2022 Elsevier B.V.

Keywords

  • Antibacterial
  • Hydrogels
  • Patents
  • Polysaccharides
  • Wound dressings
  • Wound healing

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