Prenatal stress amplifies the immediate behavioural responses to acute pain in piglets

KMD Rutherford, S Robson, R Donald, S Jarvis, DA Sandercock, Marian E Scott, A Nolan, AB Lawrence

Research output: Contribution to journalArticlepeer-review

Abstract

Pre-natal stress (PNS) or undernutrition can have numerous effects on an individual's biology throughout their lifetime. Some of these effects may be adaptive by allowing individuals to tailor their phenotype to environmental conditions. Here we investigated, in the domestic pig Sus scrofa, whether one possible consequence of a predicted adverse environment could be altered pain perception. The behavioural response of piglets to the surgical amputation (‘docking’) of their tail or a sham procedure was measured for 1 min in piglets born to mothers who either experienced mid-gestation social stress or were left undisturbed throughout pregnancy. A behavioural pain score was found to predict the docked status of piglets with high discriminant accuracy. Piglets exposed to PNS had a significantly higher pain score than controls, and for each litter of tail-docked piglets, the average pain score was correlated with mid-gestation maternal cortisol levels. The data presented here provide evidence that the experience of stress in utero can result in a heightened acute response to injury in early life. Speculatively, this may represent an adaptive alteration occurring as a consequence of a pre-natal ‘early warning’ of environmental adversity.
Original languageEnglish
Pages (from-to)452 - 454
Number of pages3
JournalBiology Letters
Volume5
Issue number4
Publication statusFirst published - 2009

Bibliographical note

521557

Keywords

  • Pain
  • Piglet
  • Pre-natal stress
  • Predictive adaptive response

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