Prevalence of hepatitis E virus in slaughter-age pigs in Scotland

C. Crossan; S. Grierson; J. Thomson; A. Ward; J. Nunez-Garcia; M. Banks; L. Scobie

doi:10.1017/S0950268814003100

Prevalence of hepatitis E virus in slaughter-age pigs in Scotland

C. Crossan, S. Grierson, J. Thomson, A. Ward, J. Nunez-Garcia, M. Banks, L. Scobie

Veterinary Services

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

The prevalence of anti-HEV isotype-specific antibodies and viraemia were investigated in serum samples collected from slaughter-age pigs (aged 22-24 weeks) from 23 farms in Scotland. Of 176 serum samples tested, 29·0% (nÂ =Â 51) were anti-HEV IgG positive, 36·9% (n = 65) anti-HEV IgA positive and 29·0% (n = 51) anti-HEV IgM positive. Overall seroprevalence (anti-HEV IgG+ and/or IgA+ and/or IgM+) was 61·4% (n = 108). HEV RNA was detected in 72/162 serum samples (44·4%). Partial sequence of ORF2 (98 nt) was obtained from eight HEV RNA-positive samples and phylogenetic analysis confirmed that they were all of genotype 3. This is the first report on the prevalence of HEV in pigs in Scotland. Given the increasing incidence of locally acquired HEV infection in the UK, evidence that HEV is a foodborne zoonosis emphasizes the need for surveillance in pigs. © 2014 Cambridge University Press.

Original language	English
Pages (from-to)	2237-2240
Journal	Epidemiology and Infection
Volume	143
Issue number	10
DOIs	https://doi.org/10.1017/S0950268814003100
Publication status	Print publication - 2014

Keywords

Hepatitis E
Zoonoses
Pigs

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S0950268814003100

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title = "Prevalence of hepatitis E virus in slaughter-age pigs in Scotland",

abstract = "The prevalence of anti-HEV isotype-specific antibodies and viraemia were investigated in serum samples collected from slaughter-age pigs (aged 22-24 weeks) from 23 farms in Scotland. Of 176 serum samples tested, 29·0% (n{\^A} ={\^A} 51) were anti-HEV IgG positive, 36·9% (n = 65) anti-HEV IgA positive and 29·0% (n = 51) anti-HEV IgM positive. Overall seroprevalence (anti-HEV IgG+ and/or IgA+ and/or IgM+) was 61·4% (n = 108). HEV RNA was detected in 72/162 serum samples (44·4%). Partial sequence of ORF2 (98 nt) was obtained from eight HEV RNA-positive samples and phylogenetic analysis confirmed that they were all of genotype 3. This is the first report on the prevalence of HEV in pigs in Scotland. Given the increasing incidence of locally acquired HEV infection in the UK, evidence that HEV is a foodborne zoonosis emphasizes the need for surveillance in pigs. {\textcopyright} 2014 Cambridge University Press.",

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author = "C. Crossan and S. Grierson and J. Thomson and A. Ward and J. Nunez-Garcia and M. Banks and L. Scobie",

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doi = "10.1017/S0950268814003100",

language = "English",

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TY - JOUR

T1 - Prevalence of hepatitis E virus in slaughter-age pigs in Scotland

AU - Crossan, C.

AU - Grierson, S.

AU - Thomson, J.

AU - Ward, A.

AU - Nunez-Garcia, J.

AU - Banks, M.

AU - Scobie, L.

PY - 2014

Y1 - 2014

N2 - The prevalence of anti-HEV isotype-specific antibodies and viraemia were investigated in serum samples collected from slaughter-age pigs (aged 22-24 weeks) from 23 farms in Scotland. Of 176 serum samples tested, 29·0% (nÂ =Â 51) were anti-HEV IgG positive, 36·9% (n = 65) anti-HEV IgA positive and 29·0% (n = 51) anti-HEV IgM positive. Overall seroprevalence (anti-HEV IgG+ and/or IgA+ and/or IgM+) was 61·4% (n = 108). HEV RNA was detected in 72/162 serum samples (44·4%). Partial sequence of ORF2 (98 nt) was obtained from eight HEV RNA-positive samples and phylogenetic analysis confirmed that they were all of genotype 3. This is the first report on the prevalence of HEV in pigs in Scotland. Given the increasing incidence of locally acquired HEV infection in the UK, evidence that HEV is a foodborne zoonosis emphasizes the need for surveillance in pigs. © 2014 Cambridge University Press.

AB - The prevalence of anti-HEV isotype-specific antibodies and viraemia were investigated in serum samples collected from slaughter-age pigs (aged 22-24 weeks) from 23 farms in Scotland. Of 176 serum samples tested, 29·0% (nÂ =Â 51) were anti-HEV IgG positive, 36·9% (n = 65) anti-HEV IgA positive and 29·0% (n = 51) anti-HEV IgM positive. Overall seroprevalence (anti-HEV IgG+ and/or IgA+ and/or IgM+) was 61·4% (n = 108). HEV RNA was detected in 72/162 serum samples (44·4%). Partial sequence of ORF2 (98 nt) was obtained from eight HEV RNA-positive samples and phylogenetic analysis confirmed that they were all of genotype 3. This is the first report on the prevalence of HEV in pigs in Scotland. Given the increasing incidence of locally acquired HEV infection in the UK, evidence that HEV is a foodborne zoonosis emphasizes the need for surveillance in pigs. © 2014 Cambridge University Press.

KW - Hepatitis E

KW - Zoonoses

KW - Pigs

U2 - 10.1017/S0950268814003100

DO - 10.1017/S0950268814003100

M3 - Article

SN - 0950-2688

VL - 143

SP - 2237

EP - 2240

JO - Epidemiology and Infection

JF - Epidemiology and Infection

IS - 10

ER -

Prevalence of hepatitis E virus in slaughter-age pigs in Scotland

Abstract

Keywords

UN SDGs

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