Progress in Hydroxyapatite-Starch Based Sustainable Biomaterials for Biomedical Bone Substitution Applications

F. Miculescu*, A. Maidaniuc, Stefan Ioan Voicu, Vijay Kumar Thakur, G. E. Stan, L. T. Ciocan

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

140 Citations (Scopus)


Hydroxyapatite is a calcium phosphate intensively proposed as a bone substitution material because of its resemblance to the constituents of minerals present in natural bone. Since hydroxyapatite's properties are mainly adequate for nonload bearing applications, different solutions are being tested for improving these properties and upgrading them near the target values of natural bone. On the other hand, starch (a natural and biodegradable polymer) and its blends with other polymers have been proposed as constituents in hydroxyapatite mixtures due to the adhesive, gelling, and swelling abilities of starch particles, useful in preparing well dispersed suspensions and consolidated ceramic bodies. This article presents the perspectives of incorporating starch and starch blends in hydroxyapatite materials. Based on the role of starch within the materials, the review covers its use as (i) a polymeric matrix in hydroxyapatite composites used as adhesives, bone cements, bone waxes, drug-delivery devices or scaffolds and (ii) a sacrificial binder for fabrication of porous hydroxyapatite scaffolds. The suitability of these materials for bone reconstruction has becomes a reachable aim considering the recent advancements in ceramic fabrication and the current possibilities of controlling the processing parameters.

Original languageEnglish
Pages (from-to)8491-8512
Number of pages22
JournalACS Sustainable Chemistry and Engineering
Issue number10
Early online date15 Sept 2017
Publication statusPrint publication - 2 Oct 2017
Externally publishedYes


  • Bone cements
  • Cellulose acetate
  • Chitosan
  • Drug-delivery systems
  • Gelatin
  • Hydroxyapatite
  • Porous ceramics
  • Scaffolds
  • Silk fibroin
  • Starch
  • Starch blends
  • Starch composites


Dive into the research topics of 'Progress in Hydroxyapatite-Starch Based Sustainable Biomaterials for Biomedical Bone Substitution Applications'. Together they form a unique fingerprint.

Cite this