Proposal for a unified nomenclature for target site mutations associated with resistance to fungicides

W Mair, F Lopez-Ruiz, G Stammler, W Clark, FJ Burnett, D Hollomon, H Ishii, TS Thind, JKM Brown, B Fraaije, H Cools, M Shaw, S Fillinger, AS Walker, EM Mellado, G Schnabel, A Mehl, RP Oliver

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Evolved resistance to fungicides is a major problem limiting our ability to control agricultural, medical and veterinary pathogens and is frequently associated with substitutions in the amino acid sequence of the target protein. The convention for describing amino-acid substitutions is to cite the wild type amino acid, the codon number and the new amino acid, using the one letter amino acid code. It has frequently been observed that orthologous amino acid mutations have been selected in different species by fungicides from the same mode of action class, but the amino acids have different numbers. These differences in numbering arise from the different lengths of the proteins in each species. The purpose of the current paper is to propose a system for unifying the labelling of amino acids in fungicide target proteins. To do this we have produced alignments between fungicide target proteins of relevant species fitted to a well-studied “archetype” species. Orthologous amino acids in all species are then assigned numerical “labels” based on the position of the amino acid in the archetype protein.
Original languageEnglish
Pages (from-to)1449 - 1459
Number of pages11
JournalPest Management Science
Volume72
Issue number8
Early online date16 Jun 2016
DOIs
Publication statusFirst published - 16 Jun 2016

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fungicide resistance
mutation
amino acids
fungicides
proteins
amino acid substitution
codons
mechanism of action
amino acid sequences
pathogens

Bibliographical note

1030769

Cite this

Mair, W ; Lopez-Ruiz, F ; Stammler, G ; Clark, W ; Burnett, FJ ; Hollomon, D ; Ishii, H ; Thind, TS ; Brown, JKM ; Fraaije, B ; Cools, H ; Shaw, M ; Fillinger, S ; Walker, AS ; Mellado, EM ; Schnabel, G ; Mehl, A ; Oliver, RP. / Proposal for a unified nomenclature for target site mutations associated with resistance to fungicides. In: Pest Management Science. 2016 ; Vol. 72, No. 8. pp. 1449 - 1459.
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Mair, W, Lopez-Ruiz, F, Stammler, G, Clark, W, Burnett, FJ, Hollomon, D, Ishii, H, Thind, TS, Brown, JKM, Fraaije, B, Cools, H, Shaw, M, Fillinger, S, Walker, AS, Mellado, EM, Schnabel, G, Mehl, A & Oliver, RP 2016, 'Proposal for a unified nomenclature for target site mutations associated with resistance to fungicides', Pest Management Science, vol. 72, no. 8, pp. 1449 - 1459. https://doi.org/10.1002/ps.4301

Proposal for a unified nomenclature for target site mutations associated with resistance to fungicides. / Mair, W; Lopez-Ruiz, F; Stammler, G; Clark, W; Burnett, FJ; Hollomon, D; Ishii, H; Thind, TS; Brown, JKM; Fraaije, B; Cools, H; Shaw, M; Fillinger, S; Walker, AS; Mellado, EM; Schnabel, G; Mehl, A; Oliver, RP.

In: Pest Management Science, Vol. 72, No. 8, 16.06.2016, p. 1449 - 1459.

Research output: Contribution to journalArticle

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