Quantitative trait loci mapping for lameness associated phenotypes in Holstein Friesian dairy cattle

Enrique Sánchez-Molano, Veysel Bay, Robert Smith, G Oikonomou, G Banos*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Lameness represents a significant challenge for the dairy cattle industry, resulting in economic losses and reduced animal health and welfare. The existence of underlying genomic variation for lameness associated traits has the potential to improve selection strategies by using genomic markers. Therefore, the aim of this study was to identify genomic regions and potential candidate genes associated with lameness traits. Lameness related lesions and digital cushion thickness were studied using records collected by our research team, farm records and a combination of both. Genome-wide analyses were performed to identify significant genomic effects and a combination of single SNP association analysis and regional heritability mapping was used to identify associated genomic regions. Significant genomic effects were identified for several lameness related traits: Two genomic regions were identified on chromosome 3 associated with digital dermatitis and interdigital hyperplasia, one genomic region on chromosome 23 associated with interdigital hyperplasia, and one genomic region on chromosome 2 associated with sole haemorrhage. Candidate genes in those regions are mainly related to immune response and fibroblast proliferation. Quantitative trait loci (QTL) identified in this study could enlighten the understanding of lameness pathogenesis, providing an opportunity to improve health and welfare in dairy cattle with the addition of these regions into selection programs.
Original languageEnglish
Article number926
JournalFrontiers in Genetics
Volume10
Early online date4 Oct 2019
DOIs
Publication statusFirst published - 4 Oct 2019

Fingerprint

Quantitative Trait Loci
Hyperplasia
Digital Dermatitis
Dairying
Phenotype
Animal Welfare
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 2
Health
Genes
Single Nucleotide Polymorphism
Fibroblasts
Chromosomes
Economics
Genome
Hemorrhage
Research
Farms

Bibliographical note

Copyright © 2019 Sánchez-Molano, Bay, Smith, Oikonomou and Banos.

Keywords

  • Dairy cattle lameness
  • Genome-wide association
  • Regional heritability mapping
  • Quantitative Trait Loci
  • Digital cushion thickness

Cite this

Sánchez-Molano, Enrique ; Bay, Veysel ; Smith, Robert ; Oikonomou, G ; Banos, G. / Quantitative trait loci mapping for lameness associated phenotypes in Holstein Friesian dairy cattle. In: Frontiers in Genetics. 2019 ; Vol. 10.
@article{183498da604c4060840d202775614067,
title = "Quantitative trait loci mapping for lameness associated phenotypes in Holstein Friesian dairy cattle",
abstract = "Lameness represents a significant challenge for the dairy cattle industry, resulting in economic losses and reduced animal health and welfare. The existence of underlying genomic variation for lameness associated traits has the potential to improve selection strategies by using genomic markers. Therefore, the aim of this study was to identify genomic regions and potential candidate genes associated with lameness traits. Lameness related lesions and digital cushion thickness were studied using records collected by our research team, farm records and a combination of both. Genome-wide analyses were performed to identify significant genomic effects and a combination of single SNP association analysis and regional heritability mapping was used to identify associated genomic regions. Significant genomic effects were identified for several lameness related traits: Two genomic regions were identified on chromosome 3 associated with digital dermatitis and interdigital hyperplasia, one genomic region on chromosome 23 associated with interdigital hyperplasia, and one genomic region on chromosome 2 associated with sole haemorrhage. Candidate genes in those regions are mainly related to immune response and fibroblast proliferation. Quantitative trait loci (QTL) identified in this study could enlighten the understanding of lameness pathogenesis, providing an opportunity to improve health and welfare in dairy cattle with the addition of these regions into selection programs.",
keywords = "Dairy cattle lameness, Genome-wide association, Regional heritability mapping, Quantitative Trait Loci, Digital cushion thickness",
author = "Enrique S{\'a}nchez-Molano and Veysel Bay and Robert Smith and G Oikonomou and G Banos",
note = "Copyright {\circledC} 2019 S{\'a}nchez-Molano, Bay, Smith, Oikonomou and Banos.",
year = "2019",
month = "10",
day = "4",
doi = "10.3389/fgene.2019.00926",
language = "English",
volume = "10",
journal = "Frontiers in Genetics",
issn = "1664-8021",
publisher = "Frontiers Media S.A.",

}

Quantitative trait loci mapping for lameness associated phenotypes in Holstein Friesian dairy cattle. / Sánchez-Molano, Enrique; Bay, Veysel; Smith, Robert ; Oikonomou, G; Banos, G.

In: Frontiers in Genetics, Vol. 10, 926, 04.10.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Quantitative trait loci mapping for lameness associated phenotypes in Holstein Friesian dairy cattle

AU - Sánchez-Molano, Enrique

AU - Bay, Veysel

AU - Smith, Robert

AU - Oikonomou, G

AU - Banos, G

N1 - Copyright © 2019 Sánchez-Molano, Bay, Smith, Oikonomou and Banos.

PY - 2019/10/4

Y1 - 2019/10/4

N2 - Lameness represents a significant challenge for the dairy cattle industry, resulting in economic losses and reduced animal health and welfare. The existence of underlying genomic variation for lameness associated traits has the potential to improve selection strategies by using genomic markers. Therefore, the aim of this study was to identify genomic regions and potential candidate genes associated with lameness traits. Lameness related lesions and digital cushion thickness were studied using records collected by our research team, farm records and a combination of both. Genome-wide analyses were performed to identify significant genomic effects and a combination of single SNP association analysis and regional heritability mapping was used to identify associated genomic regions. Significant genomic effects were identified for several lameness related traits: Two genomic regions were identified on chromosome 3 associated with digital dermatitis and interdigital hyperplasia, one genomic region on chromosome 23 associated with interdigital hyperplasia, and one genomic region on chromosome 2 associated with sole haemorrhage. Candidate genes in those regions are mainly related to immune response and fibroblast proliferation. Quantitative trait loci (QTL) identified in this study could enlighten the understanding of lameness pathogenesis, providing an opportunity to improve health and welfare in dairy cattle with the addition of these regions into selection programs.

AB - Lameness represents a significant challenge for the dairy cattle industry, resulting in economic losses and reduced animal health and welfare. The existence of underlying genomic variation for lameness associated traits has the potential to improve selection strategies by using genomic markers. Therefore, the aim of this study was to identify genomic regions and potential candidate genes associated with lameness traits. Lameness related lesions and digital cushion thickness were studied using records collected by our research team, farm records and a combination of both. Genome-wide analyses were performed to identify significant genomic effects and a combination of single SNP association analysis and regional heritability mapping was used to identify associated genomic regions. Significant genomic effects were identified for several lameness related traits: Two genomic regions were identified on chromosome 3 associated with digital dermatitis and interdigital hyperplasia, one genomic region on chromosome 23 associated with interdigital hyperplasia, and one genomic region on chromosome 2 associated with sole haemorrhage. Candidate genes in those regions are mainly related to immune response and fibroblast proliferation. Quantitative trait loci (QTL) identified in this study could enlighten the understanding of lameness pathogenesis, providing an opportunity to improve health and welfare in dairy cattle with the addition of these regions into selection programs.

KW - Dairy cattle lameness

KW - Genome-wide association

KW - Regional heritability mapping

KW - Quantitative Trait Loci

KW - Digital cushion thickness

UR - http://www.scopus.com/inward/record.url?scp=85073802901&partnerID=8YFLogxK

U2 - 10.3389/fgene.2019.00926

DO - 10.3389/fgene.2019.00926

M3 - Article

C2 - 31636655

VL - 10

JO - Frontiers in Genetics

JF - Frontiers in Genetics

SN - 1664-8021

M1 - 926

ER -