Recent Progress in Phage Therapy to Modulate Multidrug-Resistant Acinetobacter baumannii, Including in Human and Poultry

Zhang Yan, Yuanqing Lin, SG Galgano, JGM Houdijk, Weiquan Xie, Yajie Jin, Jiameng Lin, Wuqiang Song, Yijuan Fu, Xiuying Li, Wenting Chui, Wei Kan, Cai Jia, Guangwei Hu, Tao Li*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Downloads (Pure)

Abstract

Acinetobacter baumannii is a multidrug-resistant and invasive pathogen associated with theetiopathology of both an increasing number of nosocomial infections and is of relevance to poultryproduction systems. Multidrug-resistant Acinetobacter baumannii has been reported in connection tosevere challenges to clinical treatment, mostly due to an increased rate of resistance to carbapenems.Amid the possible strategies aiming to reduce the insurgence of antimicrobial resistance, phagetherapy has gained particular importance for the treatment of bacterial infections. This review summarizesthe different phage-therapy approaches currently in use for multiple-drug resistant Acinetobacterbaumannii, including single phage therapy, phage cocktails, phage–antibiotic combinationtherapy, phage-derived enzymes active on Acinetobacter baumannii and some novel technologiesbased on phage interventions. Although phage therapy represents a potential treatment solutionfor multidrug-resistant Acinetobacter baumannii, further research is needed to unravel some unansweredquestions, especially in regard to its in vivo applications, before possible routine clinical use.
Original languageEnglish
Article number1406
JournalAntibiotics
Volume11
Issue number10
Early online date13 Oct 2022
DOIs
Publication statusFirst published - 13 Oct 2022

Keywords

  • multidrug-resistant Acinetobacter baumannii
  • phage therapy

Fingerprint

Dive into the research topics of 'Recent Progress in Phage Therapy to Modulate Multidrug-Resistant Acinetobacter baumannii, Including in Human and Poultry'. Together they form a unique fingerprint.

Cite this