Refugia and anthelmintic resistance: concepts and challenges

Jane E Hodgkinson, Ray M Kaplan, Fiona Kenyon, Eric R Morgan, Andrew W Park, Steve Paterson, Simon A Babayan, Nicola J Beesley, Collette Britton, Umer Chaudhry, Stephen R Doyle, Vanessa O Ezenwa, Andy Fenton, Sue B Howell, Roz Laing, Barbara K Mable, Louise Matthews, Jennifer McIntyre, Catherine E Milne, Thomas A MorrisonJamie C Prentice, Neil D Sargison, Diana J L Williams, Adrian J Wolstenholme, Eileen Devaney*

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in 'refugia', unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions needed for refugia to work, or how transferable those are between parasite-host systems, are not known. This review, born of an international workshop, seeks to deconstruct the concept of refugia and examine its assumptions and applicability in different situations. We conclude that factors potentially important to refugia, such as the fitness cost of drug resistance, the degree of mixing between parasite sub-populations selected through treatment or not, and the impact of parasite life-history, genetics and environment on the population dynamics of resistance, vary widely between systems. The success of attempts to generate refugia to limit anthelmintic drug resistance are therefore likely to be highly dependent on the system in hand. Additional research is needed on the concept of refugia and the underlying principles for its application across systems, as well as empirical studies within systems that prove and optimise its usefulness.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalInternational Journal for Parasitology: Drugs and Drug Resistance
Volume10
Early online date17 May 2019
DOIs
Publication statusPrint publication - Aug 2019

Fingerprint

Anthelmintics
Drug Resistance
Parasites
Food Supply
Helminths
Population Dynamics
Refugium
Practice Guidelines
Population
Hand
Education
Pressure
Costs and Cost Analysis
Research

Keywords

  • Refugia
  • Anthelmintic drug
  • Resistance
  • Parasite
  • Control
  • Fitness

Cite this

Hodgkinson, J. E., Kaplan, R. M., Kenyon, F., Morgan, E. R., Park, A. W., Paterson, S., ... Devaney, E. (2019). Refugia and anthelmintic resistance: concepts and challenges. International Journal for Parasitology: Drugs and Drug Resistance, 10, 51-57. https://doi.org/10.1016/j.ijpddr.2019.05.001
Hodgkinson, Jane E ; Kaplan, Ray M ; Kenyon, Fiona ; Morgan, Eric R ; Park, Andrew W ; Paterson, Steve ; Babayan, Simon A ; Beesley, Nicola J ; Britton, Collette ; Chaudhry, Umer ; Doyle, Stephen R ; Ezenwa, Vanessa O ; Fenton, Andy ; Howell, Sue B ; Laing, Roz ; Mable, Barbara K ; Matthews, Louise ; McIntyre, Jennifer ; Milne, Catherine E ; Morrison, Thomas A ; Prentice, Jamie C ; Sargison, Neil D ; Williams, Diana J L ; Wolstenholme, Adrian J ; Devaney, Eileen. / Refugia and anthelmintic resistance: concepts and challenges. In: International Journal for Parasitology: Drugs and Drug Resistance. 2019 ; Vol. 10. pp. 51-57.
@article{7b8aa24758dc41c7b3e1758cb95fb1ab,
title = "Refugia and anthelmintic resistance: concepts and challenges",
abstract = "Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in 'refugia', unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions needed for refugia to work, or how transferable those are between parasite-host systems, are not known. This review, born of an international workshop, seeks to deconstruct the concept of refugia and examine its assumptions and applicability in different situations. We conclude that factors potentially important to refugia, such as the fitness cost of drug resistance, the degree of mixing between parasite sub-populations selected through treatment or not, and the impact of parasite life-history, genetics and environment on the population dynamics of resistance, vary widely between systems. The success of attempts to generate refugia to limit anthelmintic drug resistance are therefore likely to be highly dependent on the system in hand. Additional research is needed on the concept of refugia and the underlying principles for its application across systems, as well as empirical studies within systems that prove and optimise its usefulness.",
keywords = "Refugia, Anthelmintic drug, Resistance, Parasite, Control, Fitness",
author = "Hodgkinson, {Jane E} and Kaplan, {Ray M} and Fiona Kenyon and Morgan, {Eric R} and Park, {Andrew W} and Steve Paterson and Babayan, {Simon A} and Beesley, {Nicola J} and Collette Britton and Umer Chaudhry and Doyle, {Stephen R} and Ezenwa, {Vanessa O} and Andy Fenton and Howell, {Sue B} and Roz Laing and Mable, {Barbara K} and Louise Matthews and Jennifer McIntyre and Milne, {Catherine E} and Morrison, {Thomas A} and Prentice, {Jamie C} and Sargison, {Neil D} and Williams, {Diana J L} and Wolstenholme, {Adrian J} and Eileen Devaney",
year = "2019",
month = "8",
doi = "10.1016/j.ijpddr.2019.05.001",
language = "English",
volume = "10",
pages = "51--57",
journal = "International Journal for Parasitology: Drugs and Drug Resistance",
issn = "2211-3207",
publisher = "Elsevier BV",

}

Hodgkinson, JE, Kaplan, RM, Kenyon, F, Morgan, ER, Park, AW, Paterson, S, Babayan, SA, Beesley, NJ, Britton, C, Chaudhry, U, Doyle, SR, Ezenwa, VO, Fenton, A, Howell, SB, Laing, R, Mable, BK, Matthews, L, McIntyre, J, Milne, CE, Morrison, TA, Prentice, JC, Sargison, ND, Williams, DJL, Wolstenholme, AJ & Devaney, E 2019, 'Refugia and anthelmintic resistance: concepts and challenges', International Journal for Parasitology: Drugs and Drug Resistance, vol. 10, pp. 51-57. https://doi.org/10.1016/j.ijpddr.2019.05.001

Refugia and anthelmintic resistance: concepts and challenges. / Hodgkinson, Jane E; Kaplan, Ray M; Kenyon, Fiona; Morgan, Eric R; Park, Andrew W; Paterson, Steve; Babayan, Simon A; Beesley, Nicola J; Britton, Collette; Chaudhry, Umer; Doyle, Stephen R; Ezenwa, Vanessa O; Fenton, Andy; Howell, Sue B; Laing, Roz; Mable, Barbara K; Matthews, Louise; McIntyre, Jennifer; Milne, Catherine E; Morrison, Thomas A; Prentice, Jamie C; Sargison, Neil D; Williams, Diana J L; Wolstenholme, Adrian J; Devaney, Eileen.

In: International Journal for Parasitology: Drugs and Drug Resistance, Vol. 10, 08.2019, p. 51-57.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Refugia and anthelmintic resistance: concepts and challenges

AU - Hodgkinson, Jane E

AU - Kaplan, Ray M

AU - Kenyon, Fiona

AU - Morgan, Eric R

AU - Park, Andrew W

AU - Paterson, Steve

AU - Babayan, Simon A

AU - Beesley, Nicola J

AU - Britton, Collette

AU - Chaudhry, Umer

AU - Doyle, Stephen R

AU - Ezenwa, Vanessa O

AU - Fenton, Andy

AU - Howell, Sue B

AU - Laing, Roz

AU - Mable, Barbara K

AU - Matthews, Louise

AU - McIntyre, Jennifer

AU - Milne, Catherine E

AU - Morrison, Thomas A

AU - Prentice, Jamie C

AU - Sargison, Neil D

AU - Williams, Diana J L

AU - Wolstenholme, Adrian J

AU - Devaney, Eileen

PY - 2019/8

Y1 - 2019/8

N2 - Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in 'refugia', unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions needed for refugia to work, or how transferable those are between parasite-host systems, are not known. This review, born of an international workshop, seeks to deconstruct the concept of refugia and examine its assumptions and applicability in different situations. We conclude that factors potentially important to refugia, such as the fitness cost of drug resistance, the degree of mixing between parasite sub-populations selected through treatment or not, and the impact of parasite life-history, genetics and environment on the population dynamics of resistance, vary widely between systems. The success of attempts to generate refugia to limit anthelmintic drug resistance are therefore likely to be highly dependent on the system in hand. Additional research is needed on the concept of refugia and the underlying principles for its application across systems, as well as empirical studies within systems that prove and optimise its usefulness.

AB - Anthelmintic resistance is a threat to global food security. In order to alleviate the selection pressure for resistance and maintain drug efficacy, management strategies increasingly aim to preserve a proportion of the parasite population in 'refugia', unexposed to treatment. While persuasive in its logic, and widely advocated as best practice, evidence for the ability of refugia-based approaches to slow the development of drug resistance in parasitic helminths is currently limited. Moreover, the conditions needed for refugia to work, or how transferable those are between parasite-host systems, are not known. This review, born of an international workshop, seeks to deconstruct the concept of refugia and examine its assumptions and applicability in different situations. We conclude that factors potentially important to refugia, such as the fitness cost of drug resistance, the degree of mixing between parasite sub-populations selected through treatment or not, and the impact of parasite life-history, genetics and environment on the population dynamics of resistance, vary widely between systems. The success of attempts to generate refugia to limit anthelmintic drug resistance are therefore likely to be highly dependent on the system in hand. Additional research is needed on the concept of refugia and the underlying principles for its application across systems, as well as empirical studies within systems that prove and optimise its usefulness.

KW - Refugia

KW - Anthelmintic drug

KW - Resistance

KW - Parasite

KW - Control

KW - Fitness

U2 - 10.1016/j.ijpddr.2019.05.001

DO - 10.1016/j.ijpddr.2019.05.001

M3 - Review article

C2 - 31125837

VL - 10

SP - 51

EP - 57

JO - International Journal for Parasitology: Drugs and Drug Resistance

JF - International Journal for Parasitology: Drugs and Drug Resistance

SN - 2211-3207

ER -