Selected fungal natural products with antimicrobial properties

Dorota Jakubczyk*, F Dussart

*Corresponding author for this work

Research output: Contribution to journalReview article

4 Citations (Scopus)
8 Downloads (Pure)

Abstract

Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal “toxins”. The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here.

Original languageEnglish
Article number911
Pages (from-to)911
JournalMolecules
Volume25
Issue number4
Early online date18 Feb 2020
DOIs
Publication statusFirst published - 18 Feb 2020

Keywords

  • Antimicrobial properties
  • Antimicrobial resistance
  • Biosynthesis
  • Ergot alkaloids
  • Fungal metabolites
  • Natural products
  • Peptides
  • Polyketides
  • Terpenoids

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