Selected fungal natural products with antimicrobial properties

Dorota Jakubczyk*, F Dussart

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    52 Citations (Scopus)
    93 Downloads (Pure)

    Abstract

    Fungal natural products and their effects have been known to humankind for hundreds of years. For example, toxic ergot alkaloids produced by filamentous fungi growing on rye poisoned thousands of people and livestock throughout the Middle Ages. However, their later medicinal applications, followed by the discovery of the first class of antibiotics, penicillins and other drugs of fungal origin, such as peptidic natural products, terpenoids or polyketides, have altered the historically negative reputation of fungal “toxins”. The development of new antimicrobial drugs is currently a major global challenge, mainly due to antimicrobial resistance phenomena. Therefore, the structures, biosynthesis and antimicrobial activity of selected fungal natural products are described here.

    Original languageEnglish
    Article number911
    Pages (from-to)911
    JournalMolecules
    Volume25
    Issue number4
    Early online date18 Feb 2020
    DOIs
    Publication statusFirst published - 18 Feb 2020

    Keywords

    • Antimicrobial properties
    • Antimicrobial resistance
    • Biosynthesis
    • Ergot alkaloids
    • Fungal metabolites
    • Natural products
    • Peptides
    • Polyketides
    • Terpenoids

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