Shaping the gut microbiota by bioactive phytochemicals: An emerging approach for the prevention and treatment of human diseases

Surya Sudheer, Prateeksha Gangwar, Zeba Usmani, Minaxi Sharma, Vivek Kumar Sharma, Siva Sankar Sana, Fausto Almeida, Nawal Kishore Dubey, DhananjayaPratap Singh, Neeraj Dilbaghi, Hamid Reza Khayat Kashani*, Vijai Kumar Gupta*, Brahma Nand Singh*, Maryam Khayatkashani, Seyed Mohammad Nabavi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)
188 Downloads (Pure)


The human digestive tract is the cottage to trillions of live microorganisms, which regulate health and illness. A healthy Gut Microbiota (GM) is necessary for preventing microbial growth, body growth, obesity, cancer, diabetes, and enhancing immunity. The equilibrium in GM's composition and the presence/absence of critical species enable specific responses to be essential for the host's better health condition. Research evidences revealed that the dietary plants and their bioactive phytochemicals (BPs) play an extensive and critical role in shaping the GM to get beneficial health effects. BPs are also known to improve gastrointestinal health and reduce the risk of several diseases by modulating GM-mediated cellular and molecular processes. Regular intake of BPs-rich vegetables, fruits, and herbal preparations promotes probiotic bacteria, including Bifidobacteria and Lactobacillus species, while inhibiting unwanted gut residents' development Escherichia coli, and Salmonella typhimurium etc. Upon consumption, BPs contact the GM that gets transformed before being absorbed from the gastrointestinal tract. Biotransformation of BPs by GM is linked with the enhancement of bioactivity/toxicity diminishment of the BPs compared to parental phytochemicals. Therefore, the current review focuses on the role of BPs in shaping GM for the prevention and treatment of human diseases.

Original languageEnglish
Pages (from-to)38-63
Number of pages26
Early online date22 Oct 2021
Publication statusPrint publication - Feb 2022


  • Diabetes Mellitus/microbiology
  • Gastrointestinal Microbiome
  • Gastrointestinal Tract/microbiology
  • Humans
  • Neoplasms/microbiology
  • Obesity/microbiology
  • Phytochemicals/therapeutic use
  • Polyphenols/therapeutic use
  • Probiotics/therapeutic use


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