TY - JOUR
T1 - Shaping the gut microbiota by bioactive phytochemicals
T2 - An emerging approach for the prevention and treatment of human diseases
AU - Sudheer, Surya
AU - Gangwar, Prateeksha
AU - Usmani, Zeba
AU - Sharma, Minaxi
AU - Sharma, Vivek Kumar
AU - Sana, Siva Sankar
AU - Almeida, Fausto
AU - Dubey, Nawal Kishore
AU - Singh, DhananjayaPratap
AU - Dilbaghi, Neeraj
AU - Khayat Kashani, Hamid Reza
AU - Gupta, Vijai Kumar
AU - Singh, Brahma Nand
AU - Khayatkashani, Maryam
AU - Nabavi, Seyed Mohammad
PY - 2022/2
Y1 - 2022/2
N2 - The human digestive tract is the cottage to trillions of live microorganisms, which regulate health and illness. A healthy Gut Microbiota (GM) is necessary for preventing microbial growth, body growth, obesity, cancer, diabetes, and enhancing immunity. The equilibrium in GM's composition and the presence/absence of critical species enable specific responses to be essential for the host's better health condition. Research evidences revealed that the dietary plants and their bioactive phytochemicals (BPs) play an extensive and critical role in shaping the GM to get beneficial health effects. BPs are also known to improve gastrointestinal health and reduce the risk of several diseases by modulating GM-mediated cellular and molecular processes. Regular intake of BPs-rich vegetables, fruits, and herbal preparations promotes probiotic bacteria, including Bifidobacteria and Lactobacillus species, while inhibiting unwanted gut residents' development Escherichia coli, and Salmonella typhimurium etc. Upon consumption, BPs contact the GM that gets transformed before being absorbed from the gastrointestinal tract. Biotransformation of BPs by GM is linked with the enhancement of bioactivity/toxicity diminishment of the BPs compared to parental phytochemicals. Therefore, the current review focuses on the role of BPs in shaping GM for the prevention and treatment of human diseases.
AB - The human digestive tract is the cottage to trillions of live microorganisms, which regulate health and illness. A healthy Gut Microbiota (GM) is necessary for preventing microbial growth, body growth, obesity, cancer, diabetes, and enhancing immunity. The equilibrium in GM's composition and the presence/absence of critical species enable specific responses to be essential for the host's better health condition. Research evidences revealed that the dietary plants and their bioactive phytochemicals (BPs) play an extensive and critical role in shaping the GM to get beneficial health effects. BPs are also known to improve gastrointestinal health and reduce the risk of several diseases by modulating GM-mediated cellular and molecular processes. Regular intake of BPs-rich vegetables, fruits, and herbal preparations promotes probiotic bacteria, including Bifidobacteria and Lactobacillus species, while inhibiting unwanted gut residents' development Escherichia coli, and Salmonella typhimurium etc. Upon consumption, BPs contact the GM that gets transformed before being absorbed from the gastrointestinal tract. Biotransformation of BPs by GM is linked with the enhancement of bioactivity/toxicity diminishment of the BPs compared to parental phytochemicals. Therefore, the current review focuses on the role of BPs in shaping GM for the prevention and treatment of human diseases.
KW - Diabetes Mellitus/microbiology
KW - Gastrointestinal Microbiome
KW - Gastrointestinal Tract/microbiology
KW - Humans
KW - Neoplasms/microbiology
KW - Obesity/microbiology
KW - Phytochemicals/therapeutic use
KW - Polyphenols/therapeutic use
KW - Probiotics/therapeutic use
UR - http://www.scopus.com/inward/record.url?scp=85119058544&partnerID=8YFLogxK
U2 - 10.1016/j.biochi.2021.10.010
DO - 10.1016/j.biochi.2021.10.010
M3 - Review article
C2 - 34688789
SN - 0300-9084
VL - 193
SP - 38
EP - 63
JO - Biochimie
JF - Biochimie
ER -
