TY - JOUR
T1 - Signatures of positive selection for local adaptation of African Native Cattle populations: a review
AU - Ayalew, Wondossen
AU - Wu, Xiao-yun
AU - Tarekegn, Getinet Mekuriaw
AU - Chu, Min
AU - Liang, Chun-nian
AU - Sisay Tessema, Tesfaye
AU - Yan, Ping
PY - 2023/7
Y1 - 2023/7
N2 - Cattle are central to the lives and diverse cultures of African people. It has played a crucial role in providing valuable protein for billions of households and sources of income and employment for producers and other actors in the livestock value chains. The long-term natural selection of African cattle typically signals signatures in the genome, contributes to high genetic differentiations across breeds. This has enabled them to develop unique adaptive traits to cope with inadequate feed supply, high temperatures, high internal and external parasites, and diseases. However, these unique cattle genetic resources are threatened by indiscriminate cross-breeding, breed replacements with exotic cosmopolitan breeds, and climate change pressures. Although there are no functional genomics studies, recent advancements in genotyping and sequencing technologies have identified and annotated limited functional genes and causal variants associated with unique adaptive and economical traits of African cattle populations. These genome-wide variants serve as candidates for breed improvement and support conservation efforts for endangered cattle breeds against future climate changes. Therefore, this review plans to collate comprehensive information on the identified selection footprints to support genomic studies in African cattle to confirm the validity of the results and provide a framework for further genetic association and QTL fine mapping studies.
AB - Cattle are central to the lives and diverse cultures of African people. It has played a crucial role in providing valuable protein for billions of households and sources of income and employment for producers and other actors in the livestock value chains. The long-term natural selection of African cattle typically signals signatures in the genome, contributes to high genetic differentiations across breeds. This has enabled them to develop unique adaptive traits to cope with inadequate feed supply, high temperatures, high internal and external parasites, and diseases. However, these unique cattle genetic resources are threatened by indiscriminate cross-breeding, breed replacements with exotic cosmopolitan breeds, and climate change pressures. Although there are no functional genomics studies, recent advancements in genotyping and sequencing technologies have identified and annotated limited functional genes and causal variants associated with unique adaptive and economical traits of African cattle populations. These genome-wide variants serve as candidates for breed improvement and support conservation efforts for endangered cattle breeds against future climate changes. Therefore, this review plans to collate comprehensive information on the identified selection footprints to support genomic studies in African cattle to confirm the validity of the results and provide a framework for further genetic association and QTL fine mapping studies.
KW - adaptive trait
KW - African cattle
KW - production traits
KW - reproduction traits
UR - http://www.scopus.com/inward/record.url?scp=85165427736&partnerID=8YFLogxK
U2 - 10.1016/j.jia.2023.01.004
DO - 10.1016/j.jia.2023.01.004
M3 - Review article
SN - 2095-3119
VL - 22
SP - 1967
EP - 1984
JO - Journal of Integrative Agriculture
JF - Journal of Integrative Agriculture
IS - 7
ER -