Skeletal muscle fibre growth and growth associated myopathy in the domestic chicken

Vicky E MacRae*, Michael Mahon, Sally Gilpin, DA Sandercock, MA Mitchell

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Abstract

1. Genetic selection of broilers may have pushed muscle fibres to their maximum functional size constraints. Broiler (B), female great-grandparent (GGP) and layer (L) lines were weighed, blood sampled and killed from 5 to 25 weeks of age.
2. At 25 weeks, Pectoralis major (Pm) fibre size reached by the B (65.9 mm) and GGP (59.8 mm) were 1.5 times greater than the L (38.1 mm). In the B and GGP lines, fibre growth of the Pm markedly exceeded that of the Biceps femoris (Bf) muscle. However, in the L line, fibre growth of the Pm and Bf muscle was comparable. Connective tissue content was generally higher in the Bf than in the Pm of all lines.
3. Centralised nuclei were observed predominantly in Pm, and may regulate fibre size. Both large muscle fibres and inadequate capillary supply may induce metabolic stress in B and GGP lines due to the large diffusion distances for oxygen, metabolites and waste products. 4. Enzyme markers of muscle damage (creatine kinase (CK), lactate dehydrogenase (LDH) and aspartate amino transaminase (AST)) and histopathological analysis of Pm and Bf indicated greater myopathy in B and GGP vs L.
5. Regenerative processes were associated with oestrogen secretion. Reduced CK and LDH preceded egg yolk precursor production and increased calcium uptake for eggshell synthesis in all three lines. Oestrogen may stimulate muscle fibre regeneration and recovery as a myo-protective adaptation to potentially detrimental changes in calcium economy during egg production.
Original languageEnglish
Pages (from-to)264-272
Number of pages8
JournalBritish Poultry Science
Volume47
Issue number3
DOIs
Publication statusPrint publication - Jun 2006
Externally publishedYes

Fingerprint

grandparents
muscular diseases
Skeletal Muscle Fibers
Muscular Diseases
Chickens
chickens
Muscles
muscle fibers
Growth
creatine kinase
lactate dehydrogenase
L-Lactate Dehydrogenase
muscles
estrogens
Estrogens
broiler chickens
MM Form Creatine Kinase
Egg Shell
Waste Products
Calcium

Keywords

  • Broiler chicken
  • Layer chicken
  • Skeletal muscle pathology
  • Histopathology
  • Oestrogen
  • Myo-protection
  • Pectoralis major
  • Biceps femoris
  • Muscle fibre number
  • Muscle fibre growth
  • Creatine kinase

Cite this

MacRae, Vicky E ; Mahon, Michael ; Gilpin, Sally ; Sandercock, DA ; Mitchell, MA. / Skeletal muscle fibre growth and growth associated myopathy in the domestic chicken. In: British Poultry Science. 2006 ; Vol. 47, No. 3. pp. 264-272.
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abstract = "1. Genetic selection of broilers may have pushed muscle fibres to their maximum functional size constraints. Broiler (B), female great-grandparent (GGP) and layer (L) lines were weighed, blood sampled and killed from 5 to 25 weeks of age.2. At 25 weeks, Pectoralis major (Pm) fibre size reached by the B (65.9 mm) and GGP (59.8 mm) were 1.5 times greater than the L (38.1 mm). In the B and GGP lines, fibre growth of the Pm markedly exceeded that of the Biceps femoris (Bf) muscle. However, in the L line, fibre growth of the Pm and Bf muscle was comparable. Connective tissue content was generally higher in the Bf than in the Pm of all lines.3. Centralised nuclei were observed predominantly in Pm, and may regulate fibre size. Both large muscle fibres and inadequate capillary supply may induce metabolic stress in B and GGP lines due to the large diffusion distances for oxygen, metabolites and waste products. 4. Enzyme markers of muscle damage (creatine kinase (CK), lactate dehydrogenase (LDH) and aspartate amino transaminase (AST)) and histopathological analysis of Pm and Bf indicated greater myopathy in B and GGP vs L.5. Regenerative processes were associated with oestrogen secretion. Reduced CK and LDH preceded egg yolk precursor production and increased calcium uptake for eggshell synthesis in all three lines. Oestrogen may stimulate muscle fibre regeneration and recovery as a myo-protective adaptation to potentially detrimental changes in calcium economy during egg production.",
keywords = "Broiler chicken, Layer chicken, Skeletal muscle pathology, Histopathology, Oestrogen, Myo-protection, Pectoralis major, Biceps femoris, Muscle fibre number, Muscle fibre growth, Creatine kinase",
author = "MacRae, {Vicky E} and Michael Mahon and Sally Gilpin and DA Sandercock and MA Mitchell",
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pages = "264--272",
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Skeletal muscle fibre growth and growth associated myopathy in the domestic chicken. / MacRae, Vicky E; Mahon, Michael ; Gilpin, Sally; Sandercock, DA; Mitchell, MA.

In: British Poultry Science, Vol. 47, No. 3, 06.2006, p. 264-272.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Skeletal muscle fibre growth and growth associated myopathy in the domestic chicken

AU - MacRae, Vicky E

AU - Mahon, Michael

AU - Gilpin, Sally

AU - Sandercock, DA

AU - Mitchell, MA

PY - 2006/6

Y1 - 2006/6

N2 - 1. Genetic selection of broilers may have pushed muscle fibres to their maximum functional size constraints. Broiler (B), female great-grandparent (GGP) and layer (L) lines were weighed, blood sampled and killed from 5 to 25 weeks of age.2. At 25 weeks, Pectoralis major (Pm) fibre size reached by the B (65.9 mm) and GGP (59.8 mm) were 1.5 times greater than the L (38.1 mm). In the B and GGP lines, fibre growth of the Pm markedly exceeded that of the Biceps femoris (Bf) muscle. However, in the L line, fibre growth of the Pm and Bf muscle was comparable. Connective tissue content was generally higher in the Bf than in the Pm of all lines.3. Centralised nuclei were observed predominantly in Pm, and may regulate fibre size. Both large muscle fibres and inadequate capillary supply may induce metabolic stress in B and GGP lines due to the large diffusion distances for oxygen, metabolites and waste products. 4. Enzyme markers of muscle damage (creatine kinase (CK), lactate dehydrogenase (LDH) and aspartate amino transaminase (AST)) and histopathological analysis of Pm and Bf indicated greater myopathy in B and GGP vs L.5. Regenerative processes were associated with oestrogen secretion. Reduced CK and LDH preceded egg yolk precursor production and increased calcium uptake for eggshell synthesis in all three lines. Oestrogen may stimulate muscle fibre regeneration and recovery as a myo-protective adaptation to potentially detrimental changes in calcium economy during egg production.

AB - 1. Genetic selection of broilers may have pushed muscle fibres to their maximum functional size constraints. Broiler (B), female great-grandparent (GGP) and layer (L) lines were weighed, blood sampled and killed from 5 to 25 weeks of age.2. At 25 weeks, Pectoralis major (Pm) fibre size reached by the B (65.9 mm) and GGP (59.8 mm) were 1.5 times greater than the L (38.1 mm). In the B and GGP lines, fibre growth of the Pm markedly exceeded that of the Biceps femoris (Bf) muscle. However, in the L line, fibre growth of the Pm and Bf muscle was comparable. Connective tissue content was generally higher in the Bf than in the Pm of all lines.3. Centralised nuclei were observed predominantly in Pm, and may regulate fibre size. Both large muscle fibres and inadequate capillary supply may induce metabolic stress in B and GGP lines due to the large diffusion distances for oxygen, metabolites and waste products. 4. Enzyme markers of muscle damage (creatine kinase (CK), lactate dehydrogenase (LDH) and aspartate amino transaminase (AST)) and histopathological analysis of Pm and Bf indicated greater myopathy in B and GGP vs L.5. Regenerative processes were associated with oestrogen secretion. Reduced CK and LDH preceded egg yolk precursor production and increased calcium uptake for eggshell synthesis in all three lines. Oestrogen may stimulate muscle fibre regeneration and recovery as a myo-protective adaptation to potentially detrimental changes in calcium economy during egg production.

KW - Broiler chicken

KW - Layer chicken

KW - Skeletal muscle pathology

KW - Histopathology

KW - Oestrogen

KW - Myo-protection

KW - Pectoralis major

KW - Biceps femoris

KW - Muscle fibre number

KW - Muscle fibre growth

KW - Creatine kinase

U2 - https://doi.org/10.1080/00071660600753615

DO - https://doi.org/10.1080/00071660600753615

M3 - Article

VL - 47

SP - 264

EP - 272

JO - British Poultry Science

JF - British Poultry Science

SN - 0007-1668

IS - 3

ER -