Status and future scope of plant-based green hydrogels in biomedical engineering

Reza Mohammadinejad*, Hajar Maleki, Eneko Larrañeta, André R. Fajardo, Amirala Bakhshian Nik, Amin Shavandi, Amir Sheikhi, Mansour Ghorbanpour, Mehdi Farokhi, Praveen Govindh, Etienne Cabane, Susan Azizi, Amir Reza Aref, Masoud Mozafari, Mehdi Mehrali, Sabu Thomas, João F. Mano, Yogendra Kumar Mishra, Vijay Kumar Thakur

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

159 Citations (Scopus)


Hydrogels are the most iconic class of soft materials, and since their first report in the literature, they have attracted the attention of uncountable researchers. Over the past two decades, hydrogels have become smart and sophisticated materials with numerous applications. This class of soft materials have been playing a significant role in biomedicine due to their tunable and often programmable properties. Hydrogels from renewable polymers have been popularized in biomedical applications as they are often biocompatible, easily accessible, and inexpensive. The challenge however has been to find an ideal plant-based hydrogel for biomedicine that can mimic critical properties of human tissues in terms of structure, function, and performance. In addition, natural polymers can readily be functionalized to engineer their chemical and physical uproperties pertinent to drug delivery and tissue engineering. Here, the most recent advances in the synthesis, fabrication, and applications of plant-based hydrogels in biomedical engineering are reviewed. We cover essential and updated information about plants as green sources of biopolymers for hydrogel synthesis, general aspects of hydrogels and plant-based hydrogels, and thorough discussion regarding the use of such hydrogels in the biomedical engineering area. Furthermore, this review details the present status of the field and answers several important questions about the potential of plant-based hydrogels in advanced biomedical applications including therapeutics, tissue engineering, wound dressing, and diagnostics., etc.

Original languageEnglish
Pages (from-to)213-246
Number of pages34
JournalApplied Materials Today
Early online date12 Jun 2019
Publication statusPrint publication - Sept 2019
Externally publishedYes


  • Advanced materials
  • Biomaterials
  • Green hydrogels
  • Hydrogels
  • Tissue engineering
  • Wound healing


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