TY - JOUR
T1 - Structural and temporal variation in genetic diversity of European spring two-row barley cultivars and association mapping of quantitative traits
AU - Tondelli, Alessandro
AU - Xu, Xin
AU - Moragues, Marc
AU - Sharma, Rajiv
AU - Schnaithmann, Florian
AU - Ingvardsen, Christina
AU - Manninen, Outi
AU - Comadran, Jordi
AU - Russell, Joanne
AU - Waugh, Robbie
AU - Schulman, Alan H.
AU - Pillen, Klaus
AU - Rasmussen, Søren K.
AU - Kilian, Benjamin
AU - Cattivelli, Luigi
AU - Thomas, William T. B.
AU - Flavell, Andrew J.
PY - 2013/8
Y1 - 2013/8
N2 - Two hundred sixteen barley (Hordeum vulgare L.) cultivars were selected to represent the diversity and history of European spring two-row barley breeding and to search for alleles controlling agronomic traits by association genetics. The germplasm was genotyped with 7864 gene-based single nucleotide polymorphism markers and corresponding field trial trait data relating to growth and straw strength were obtained at multiple European sites. Analysis of the marker data by statistical population genetics approaches revealed two important trends in the genetic diversity of European two-row spring barley, namely, i) directional selection for approximately 14% of total genetic variation of the population in the last approximately 50 yr and ii) highly uneven genomic distribution of genetic diversity. Association analysis of the phenotypic and genotypic data identified multiple loci affecting the traits investigated, some of which co-map with selected regions. Collectively, these data show that the genetic makeup of European two-row spring barley is evolving under breeder selection, with signs of extinction of diversity in some genomic regions, suggesting that “breeding the best with the best” is leading towards fixation of some breeder targets. Nevertheless, modern germplasm also retains many regions of high diversity, suggesting that site-specific genetic approaches for allele identification and crop improvement such as association genetics are likely to be successful.
AB - Two hundred sixteen barley (Hordeum vulgare L.) cultivars were selected to represent the diversity and history of European spring two-row barley breeding and to search for alleles controlling agronomic traits by association genetics. The germplasm was genotyped with 7864 gene-based single nucleotide polymorphism markers and corresponding field trial trait data relating to growth and straw strength were obtained at multiple European sites. Analysis of the marker data by statistical population genetics approaches revealed two important trends in the genetic diversity of European two-row spring barley, namely, i) directional selection for approximately 14% of total genetic variation of the population in the last approximately 50 yr and ii) highly uneven genomic distribution of genetic diversity. Association analysis of the phenotypic and genotypic data identified multiple loci affecting the traits investigated, some of which co-map with selected regions. Collectively, these data show that the genetic makeup of European two-row spring barley is evolving under breeder selection, with signs of extinction of diversity in some genomic regions, suggesting that “breeding the best with the best” is leading towards fixation of some breeder targets. Nevertheless, modern germplasm also retains many regions of high diversity, suggesting that site-specific genetic approaches for allele identification and crop improvement such as association genetics are likely to be successful.
UR - http://www.mendeley.com/research/structural-temporal-variation-genetic-diversity-european-spring-tworow-barley-cultivars-association
U2 - 10.3835/plantgenome2013.03.0007
DO - 10.3835/plantgenome2013.03.0007
M3 - Article
SN - 1940-3372
VL - 6
JO - Plant Genome
JF - Plant Genome
IS - 2
ER -