Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe2O4 Nanoparticles for Anticancer and Antibacterial Applications

Faten Eshrati Yeganeh, Amir Eshrati Yeganeh, Bahareh Farasati Far, Afsoun Mansouri, Belay Zeleke Sibuh, Saravanan Krishnan, Soumya Pandit, Walaa F. Alsanie, Vijay Kumar Thakur*, Piyush Kumar Gupta

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens.

Original languageEnglish
Article number2286
JournalNanomaterials
Volume12
Issue number13
Early online date3 Jul 2022
DOIs
Publication statusFirst published - 3 Jul 2022

Keywords

  • antibacterial
  • anticancer
  • cytotoxicity
  • drug release
  • methionine-NiFe2O4 nanoparticles

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