Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe2O4 Nanoparticles for Anticancer and Antibacterial Applications

Faten Eshrati Yeganeh; Amir Eshrati Yeganeh; Bahareh Farasati Far; Afsoun Mansouri; Belay Zeleke Sibuh; Saravanan Krishnan; Soumya Pandit; Walaa F. Alsanie; Vijay Kumar Thakur; Piyush Kumar Gupta

doi:10.3390/nano12132286

Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe2O4 Nanoparticles for Anticancer and Antibacterial Applications

Faten Eshrati Yeganeh, Amir Eshrati Yeganeh, Bahareh Farasati Far, Afsoun Mansouri, Belay Zeleke Sibuh, Saravanan Krishnan, Soumya Pandit, Walaa F. Alsanie, Vijay Kumar Thakur^*, Piyush Kumar Gupta

^*Corresponding author for this work

Biorefining And Advanced Materials Research Centre

Research output: Contribution to journal › Article › peer-review

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Abstract

In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens.

Original language	English
Article number	2286
Journal	Nanomaterials
Volume	12
Issue number	13
Early online date	3 Jul 2022
DOIs	https://doi.org/10.3390/nano12132286
Publication status	First published - 3 Jul 2022

Keywords

antibacterial
anticancer
cytotoxicity
drug release
methionine-NiFe2O4 nanoparticles

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10.3390/nano12132286Licence: CC BY

nanomaterials-12-02286-v2Final published version, 4.1 MBLicence: CC BY

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Yeganeh, F. E., Yeganeh, A. E., Far, B. F., Mansouri, A., Sibuh, B. Z., Krishnan, S., Pandit, S., Alsanie, W. F., Thakur, V. K., & Gupta, P. K. (2022). Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe2O4 Nanoparticles for Anticancer and Antibacterial Applications. Nanomaterials, 12(13), Article 2286. Advance online publication. https://doi.org/10.3390/nano12132286

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title = "Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe2O4 Nanoparticles for Anticancer and Antibacterial Applications",

abstract = "In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens.",

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author = "Yeganeh, {Faten Eshrati} and Yeganeh, {Amir Eshrati} and Far, {Bahareh Farasati} and Afsoun Mansouri and Sibuh, {Belay Zeleke} and Saravanan Krishnan and Soumya Pandit and Alsanie, {Walaa F.} and Thakur, {Vijay Kumar} and Gupta, {Piyush Kumar}",

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AU - Yeganeh, Faten Eshrati

AU - Yeganeh, Amir Eshrati

AU - Far, Bahareh Farasati

AU - Mansouri, Afsoun

AU - Sibuh, Belay Zeleke

AU - Krishnan, Saravanan

AU - Pandit, Soumya

AU - Alsanie, Walaa F.

AU - Thakur, Vijay Kumar

AU - Gupta, Piyush Kumar

PY - 2022/7/3

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AB - In the present study, nickel ferrite (NiFe2O4)-based smart magnetic nanoparticles were fabricated and coated with methionine. Physiochemical characterization of the obtained Met-NiFe2O4 nanoparticles revealed the presence of methionine coating over the nanoparticle surface. Drug release study indicated that Tet-Met-NiFe2O4 nanoparticles possess pH-responsive controlled drug release behavior for tetracycline (Tet). The drug loading content for Tet was found to be 0.27 mg/L of nanoparticles. In vitro cytotoxicity test showed that the Met-NiFe2O4 nanoparticles is biocompatible. Moreover, this magnetic nanostructured material shown strong anticancer property as these nanomaterials significantly reduced the viability of A375 cells when compared to free Tet solution. In addition, Tet-Met-NiFe2O4 nanoparticles also showed strong antibacterial activity against different bacterial pathogens.

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KW - anticancer

KW - cytotoxicity

KW - drug release

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ER -

Synthesis and Characterization of Tetracycline Loaded Methionine-Coated NiFe2O4 Nanoparticles for Anticancer and Antibacterial Applications

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