Tapping Into Actinobacterial Genomes for Natural Product Discovery

Tanim Arpit Singh, Ajit Kumar Passari*, Anjana Jajoo, Sheetal Bhasin*, Vijai Kumar Gupta, Abeer Hashem, Abdulaziz A. Alqarawi, Elsayed Fathi Abd_Allah

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The presence of secondary metabolite biosynthetic gene clusters (BGCs) makes actinobacteria well-known producers of diverse metabolites. These ubiquitous microbes are extensively exploited for their ability to synthesize diverse secondary metabolites. The extent of their ability to synthesize various molecules is yet to be evaluated. Current advancements in genome sequencing, metabolomics, and bioinformatics have provided a plethora of information about the mechanism of synthesis of these bioactive molecules. Accessing the biosynthetic gene cluster responsible for the production of metabolites has always been a challenging assignment. The genomic approach developments have opened a new gateway for examining and manipulating novel antibiotic gene clusters. These advancements have now developed a better understanding of actinobacterial physiology and their genetic regulation for the prolific production of natural products. These new approaches provide a unique opportunity to discover novel bioactive compounds that might replenish antibiotics’ exhausted stock and counter the microbes’ resistance crisis.
Original languageEnglish
Article number655620
Pages (from-to)655620
JournalFrontiers in Microbiology
Volume12
Early online date22 Jun 2021
DOIs
Publication statusFirst published - 22 Jun 2021

Keywords

  • actinobacteria
  • antibiotics
  • biosynthetic gene cluster
  • genomics
  • secondary metabolites

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