Testing for Albendazole resistance in rural southern Kyrgyzstan

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Abstract

The Kyrgyz people are traditionally pastoral nomads. After the collapse of the Soviet Union, infrastructure toremote pastures fell into disrepair resulting in overgrazing of pastures closer to villages and higher parasite burdens. Most farmers are reliant on Albendazole; a group 1, broad spectrum anthelmintic. However, resistance toAlbendazole has been widely documented in other countries.To determine whether resistance to Albendazole is present in Southern Kyrgyzstan. MethodFrom January to AprilMay 2018, households with sheep in the Osh oblast were interviewed about husbandrypractices, anthelmintic dosing strategy and pasture management. Fresh faecal samples were collected andgastrointestinal nematodes and Fasciola hepatica eggs were counted using the McMaster’s technique. If faecal eggcount was >300 nematode eggs per gram or >100 F. hepatica eggs per gram, the sheep were treated withAlbendazole in accordance with the datasheet. Нe gastrointestinal nematode and F. hepatica faecal egg countswere repeated with fresh faecal samples 2 and 3 weeks respectively Dіer the initial test. If there was <95% reductionin the faecal egg count, the sheep were retreated with either oral Ivermectin for gastrointestinal nematodes orOxyclozanide for F. hepatica. Following retreatment, a third faecal sample was collected and eggs counted usingthe McMasters technique 2 or 3 weeks later respectively.Of the 43 households tested, 1 had <95% reduction in gastrointestinal nematode eggs and 4 had <95% reductionin F. hepatica eggs. Retreatment with Ivermectin and Oxyclozanide respectively resulted in zero eggs per gram offaeces.This study provides evidence of Albendazole resistance in Southern Kyrgyzstan. Programs designed to increaseawareness of anthelmintic resistance, provide training in good parasite management to farmers and resourceveterinarians with parasite laboratories would be a valuable contribution to improving animal health andproductivity. In addition, importing a wider range of veterinary medicines so households where anthelminticresistance is already present have alternative drug choices is essential.
Original languageEnglish
Article number1000221
Number of pages4
JournalTropical Medicine and Surgery
Volume6
Issue number1
Early online date19 Dec 2018
DOIs
Publication statusFirst published - 19 Dec 2018
Externally publishedYes

Keywords

  • Albendazole anthelmintic resistance kyrgyzstan

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