The colloquy between microbiota and the immune system in colon cancer: repercussions on the cancer therapy

Soumya Pal, Adesh Kumar Saini, Ankur Kaushal, Shagun Gupta, Naseem A Gaur, Anil K Chhillar, Anil K Sharma, Vijai Kumar Gupta, Reena V Saini*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Colorectal cancer is the second leading cause of cancer deaths worldwide and has engrossed researchers' attention toward its detection and prevention at early stages. Primarily associated with genetic and environmental risk factors, the disease has also shown its emergence due to dysbiosis in microbiota. The microbiota not only plays a role in modulating the metabolisms of metastatic tissue but also has a keen role in cancer therapy. The immune cells are responsible for secreting various chemokines and cytokines, and activating pattern recognition receptors by different microbes can lead to the trail by which these cells regulate cancer. Furthermore, mixed immune reactions involving NK cells, tumor-associated macrophages, and lymphocytes have shown their connection with the microbial counterpart of the disease. The microbes like Bacteroides fragilis, Fusobacterium nucleatum, and Enterococcus faecalis and their metabolites have engendered inflammatory reactions in the tumor microenvironment. Hence the interplay between immune cells and various microbes is utilized to study the changing metastasis stage. Targeting either immune cells or microbiota could not serve as a key to tackling this deadly disorder. However, harnessing their complementation towards the disease can be a powerful weapon for developing therapy and diagnostic/prognostic markers. In this review, we have discussed various immune reactions and microbiome interplay in CRC, intending to evaluate the effectiveness of chemotherapy and immunotherapy and their parallel relationship.

Original languageEnglish
Pages (from-to)3478-3485
Number of pages8
JournalCurrent Pharmaceutical Design
Volume28
Issue number43
Early online date8 Dec 2022
DOIs
Publication statusFirst published - 8 Dec 2022

Bibliographical note

Copyright© Bentham Science Publishers

Keywords

  • microbes
  • immune cells
  • Tumor Microenvironment
  • immunotherapy
  • microbiota
  • colorectal cancer
  • Colorectal cancer
  • tumor microenvironment

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