The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen

C J Newbold; R J Wallace; N D Walker

doi:10.1111/j.1365-2672.1993.tb02757.x

The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen

C J Newbold, R J Wallace, N D Walker

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The Gram-negative rumen bacteria Fibrobacter succinogenes S85, Prevotella ruminicola M384 and Veillonella parvula L59 were grown in media containing successively increasing concentrations of the ionophores, monensin and tetronasin. All three species became more resistant to the ionophore with which they were grown. Increased resistance to one ionophore caused increased resistance to the other, and cross-resistance to another ionophore--lasalocid--and an antibiotic--avoparcin. Recovery of tetronasin-resistant bacteria from the rumen of monensin-fed sheep increased and vice versa, indicating that similar cross-resistance occurred in vivo.

Original language	English
Pages (from-to)	129-34
Number of pages	6
Journal	Journal of Applied Microbiology
Volume	75
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2672.1993.tb02757.x
Publication status	Print publication - Aug 1993
Externally published	Yes

Keywords

Animals
Anti-Bacterial Agents/pharmacology
Bacteroides/drug effects
Colony Count, Microbial
Drug Resistance, Microbial
Fermentation/drug effects
Furans/pharmacology
Gram-Negative Anaerobic Bacteria/drug effects
Ionophores/pharmacology
Monensin/pharmacology
Rumen/microbiology
Sheep
Veillonella/drug effects

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10.1111/j.1365-2672.1993.tb02757.x

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title = "The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen",

abstract = "The Gram-negative rumen bacteria Fibrobacter succinogenes S85, Prevotella ruminicola M384 and Veillonella parvula L59 were grown in media containing successively increasing concentrations of the ionophores, monensin and tetronasin. All three species became more resistant to the ionophore with which they were grown. Increased resistance to one ionophore caused increased resistance to the other, and cross-resistance to another ionophore--lasalocid--and an antibiotic--avoparcin. Recovery of tetronasin-resistant bacteria from the rumen of monensin-fed sheep increased and vice versa, indicating that similar cross-resistance occurred in vivo.",

keywords = "Animals, Anti-Bacterial Agents/pharmacology, Bacteroides/drug effects, Colony Count, Microbial, Drug Resistance, Microbial, Fermentation/drug effects, Furans/pharmacology, Gram-Negative Anaerobic Bacteria/drug effects, Ionophores/pharmacology, Monensin/pharmacology, Rumen/microbiology, Sheep, Veillonella/drug effects",

author = "Newbold, {C J} and Wallace, {R J} and Walker, {N D}",

year = "1993",

month = aug,

doi = "10.1111/j.1365-2672.1993.tb02757.x",

language = "English",

volume = "75",

pages = "129--34",

journal = "Journal of Applied Microbiology",

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T1 - The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen

AU - Newbold, C J

AU - Wallace, R J

AU - Walker, N D

PY - 1993/8

Y1 - 1993/8

N2 - The Gram-negative rumen bacteria Fibrobacter succinogenes S85, Prevotella ruminicola M384 and Veillonella parvula L59 were grown in media containing successively increasing concentrations of the ionophores, monensin and tetronasin. All three species became more resistant to the ionophore with which they were grown. Increased resistance to one ionophore caused increased resistance to the other, and cross-resistance to another ionophore--lasalocid--and an antibiotic--avoparcin. Recovery of tetronasin-resistant bacteria from the rumen of monensin-fed sheep increased and vice versa, indicating that similar cross-resistance occurred in vivo.

AB - The Gram-negative rumen bacteria Fibrobacter succinogenes S85, Prevotella ruminicola M384 and Veillonella parvula L59 were grown in media containing successively increasing concentrations of the ionophores, monensin and tetronasin. All three species became more resistant to the ionophore with which they were grown. Increased resistance to one ionophore caused increased resistance to the other, and cross-resistance to another ionophore--lasalocid--and an antibiotic--avoparcin. Recovery of tetronasin-resistant bacteria from the rumen of monensin-fed sheep increased and vice versa, indicating that similar cross-resistance occurred in vivo.

KW - Animals

KW - Anti-Bacterial Agents/pharmacology

KW - Bacteroides/drug effects

KW - Colony Count, Microbial

KW - Drug Resistance, Microbial

KW - Fermentation/drug effects

KW - Furans/pharmacology

KW - Gram-Negative Anaerobic Bacteria/drug effects

KW - Ionophores/pharmacology

KW - Monensin/pharmacology

KW - Rumen/microbiology

KW - Sheep

KW - Veillonella/drug effects

U2 - 10.1111/j.1365-2672.1993.tb02757.x

DO - 10.1111/j.1365-2672.1993.tb02757.x

M3 - Article

C2 - 8407673

SN - 0021-8847

VL - 75

SP - 129

EP - 134

JO - Journal of Applied Microbiology

JF - Journal of Applied Microbiology

IS - 2

ER -

The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen

Abstract

Keywords

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