The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen

C J Newbold, R J Wallace, N D Walker

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The Gram-negative rumen bacteria Fibrobacter succinogenes S85, Prevotella ruminicola M384 and Veillonella parvula L59 were grown in media containing successively increasing concentrations of the ionophores, monensin and tetronasin. All three species became more resistant to the ionophore with which they were grown. Increased resistance to one ionophore caused increased resistance to the other, and cross-resistance to another ionophore--lasalocid--and an antibiotic--avoparcin. Recovery of tetronasin-resistant bacteria from the rumen of monensin-fed sheep increased and vice versa, indicating that similar cross-resistance occurred in vivo.

Original languageEnglish
Pages (from-to)129-34
Number of pages6
JournalJournal of Applied Microbiology
Volume75
Issue number2
DOIs
Publication statusPrint publication - Aug 1993
Externally publishedYes

Fingerprint

Monensin
Ionophores
Rumen
Fermentation
Bacteria
Prevotella ruminicola
Fibrobacter
Lasalocid
Veillonella
Gram-Negative Bacteria
Sheep
Anti-Bacterial Agents
tetronasin

Keywords

  • Animals
  • Anti-Bacterial Agents/pharmacology
  • Bacteroides/drug effects
  • Colony Count, Microbial
  • Drug Resistance, Microbial
  • Fermentation/drug effects
  • Furans/pharmacology
  • Gram-Negative Anaerobic Bacteria/drug effects
  • Ionophores/pharmacology
  • Monensin/pharmacology
  • Rumen/microbiology
  • Sheep
  • Veillonella/drug effects

Cite this

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title = "The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen",
abstract = "The Gram-negative rumen bacteria Fibrobacter succinogenes S85, Prevotella ruminicola M384 and Veillonella parvula L59 were grown in media containing successively increasing concentrations of the ionophores, monensin and tetronasin. All three species became more resistant to the ionophore with which they were grown. Increased resistance to one ionophore caused increased resistance to the other, and cross-resistance to another ionophore--lasalocid--and an antibiotic--avoparcin. Recovery of tetronasin-resistant bacteria from the rumen of monensin-fed sheep increased and vice versa, indicating that similar cross-resistance occurred in vivo.",
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The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen. / Newbold, C J; Wallace, R J; Walker, N D.

In: Journal of Applied Microbiology, Vol. 75, No. 2, 08.1993, p. 129-34.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The effect of tetronasin and monensin on fermentation, microbial numbers and the development of ionophore-resistant bacteria in the rumen

AU - Newbold, C J

AU - Wallace, R J

AU - Walker, N D

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AB - The Gram-negative rumen bacteria Fibrobacter succinogenes S85, Prevotella ruminicola M384 and Veillonella parvula L59 were grown in media containing successively increasing concentrations of the ionophores, monensin and tetronasin. All three species became more resistant to the ionophore with which they were grown. Increased resistance to one ionophore caused increased resistance to the other, and cross-resistance to another ionophore--lasalocid--and an antibiotic--avoparcin. Recovery of tetronasin-resistant bacteria from the rumen of monensin-fed sheep increased and vice versa, indicating that similar cross-resistance occurred in vivo.

KW - Animals

KW - Anti-Bacterial Agents/pharmacology

KW - Bacteroides/drug effects

KW - Colony Count, Microbial

KW - Drug Resistance, Microbial

KW - Fermentation/drug effects

KW - Furans/pharmacology

KW - Gram-Negative Anaerobic Bacteria/drug effects

KW - Ionophores/pharmacology

KW - Monensin/pharmacology

KW - Rumen/microbiology

KW - Sheep

KW - Veillonella/drug effects

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DO - https://doi.org/10.1111/j.1365-2672.1993.tb02757.x

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JO - Journal of Applied Microbiology

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