The opportunity to eradicate peste des petits ruminants

Jeffrey C Mariner, Bryony A Jones, Karl M Rich, Samuel Thevasagayam, John Anderson, Martyn Jeggo, Yi Cai, Andrew R Peters, Peter L Roeder

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Peste des petits ruminants (PPR) is a highly infectious disease of sheep and goats that is caused by PPR virus, a member of the genus Morbillivirus that includes the viruses that cause rinderpest (RP) in cattle. RP was the first animal disease to be globally eradicated in 2011 and is only the second disease, after smallpox, to have ever been eradicated. PPR is one of the principal constraints to small ruminant production in Africa, Asia, and the Middle East. The epidemiology of PPR and RP as well as the technologies available for their diagnosis and control are similar. The conditions that favored the eradication of RP are also largely present for PPR. In this work, we outline the evolving strategy for eradication in light of current opportunities and challenges, as well as the lessons from other eradication programs in animal and human health. The global PPR situation and technology for its control are summarized. A strategy based on the lessons from previous eradication efforts that integrate epidemiology, social science, and economics as tools to target and motivate vaccination is summarized. Major aspects of the cost and benefit-cost analysis of the indicated program are presented. The overall undiscounted cost of eradication was estimated as $3.1 billion, and the benefit-cost ratio for the most likely scenario was estimated at 33.8. We close with a discussion of the possible next steps.

Original languageEnglish
Pages (from-to)3499-506
Number of pages8
JournalJournal of Immunology
Volume196
Issue number9
Early online date16 Apr 2016
DOIs
Publication statusPrint publication - 1 May 2016

Fingerprint

Peste-des-Petits-Ruminants
Rinderpest
Cost-Benefit Analysis
Peste-des-petits-ruminants virus
Epidemiology
Rinderpest virus
Morbillivirus
Technology
Costs and Cost Analysis
Animal Diseases
Smallpox
Middle East
Social Sciences
Ruminants
Goats
Communicable Diseases
Sheep
Vaccination
Economics
Health

Bibliographical note

Copyright © 2016 by The American Association of Immunologists, Inc.

Keywords

  • Africa/epidemiology
  • Animals
  • Antibodies, Viral/blood
  • Asia/epidemiology
  • Cattle/virology
  • Cattle Diseases/prevention & control
  • Disease Eradication/economics
  • Enzyme-Linked Immunosorbent Assay
  • Europe/epidemiology
  • Goat Diseases/prevention & control
  • Goats/virology
  • Peste-des-Petits-Ruminants/epidemiology
  • Peste-des-petits-ruminants virus/immunology
  • Sheep/virology
  • Sheep Diseases/prevention & control
  • Vaccination/veterinary
  • Viral Vaccines/administration & dosage

Cite this

Mariner, J. C., Jones, B. A., Rich, K. M., Thevasagayam, S., Anderson, J., Jeggo, M., ... Roeder, P. L. (2016). The opportunity to eradicate peste des petits ruminants. Journal of Immunology, 196(9), 3499-506. https://doi.org/10.4049/jimmunol.1502625
Mariner, Jeffrey C ; Jones, Bryony A ; Rich, Karl M ; Thevasagayam, Samuel ; Anderson, John ; Jeggo, Martyn ; Cai, Yi ; Peters, Andrew R ; Roeder, Peter L. / The opportunity to eradicate peste des petits ruminants. In: Journal of Immunology. 2016 ; Vol. 196, No. 9. pp. 3499-506.
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Mariner, JC, Jones, BA, Rich, KM, Thevasagayam, S, Anderson, J, Jeggo, M, Cai, Y, Peters, AR & Roeder, PL 2016, 'The opportunity to eradicate peste des petits ruminants', Journal of Immunology, vol. 196, no. 9, pp. 3499-506. https://doi.org/10.4049/jimmunol.1502625

The opportunity to eradicate peste des petits ruminants. / Mariner, Jeffrey C; Jones, Bryony A; Rich, Karl M; Thevasagayam, Samuel; Anderson, John; Jeggo, Martyn; Cai, Yi; Peters, Andrew R; Roeder, Peter L.

In: Journal of Immunology, Vol. 196, No. 9, 01.05.2016, p. 3499-506.

Research output: Contribution to journalArticle

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AU - Mariner, Jeffrey C

AU - Jones, Bryony A

AU - Rich, Karl M

AU - Thevasagayam, Samuel

AU - Anderson, John

AU - Jeggo, Martyn

AU - Cai, Yi

AU - Peters, Andrew R

AU - Roeder, Peter L

N1 - Copyright © 2016 by The American Association of Immunologists, Inc.

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Y1 - 2016/5/1

N2 - Peste des petits ruminants (PPR) is a highly infectious disease of sheep and goats that is caused by PPR virus, a member of the genus Morbillivirus that includes the viruses that cause rinderpest (RP) in cattle. RP was the first animal disease to be globally eradicated in 2011 and is only the second disease, after smallpox, to have ever been eradicated. PPR is one of the principal constraints to small ruminant production in Africa, Asia, and the Middle East. The epidemiology of PPR and RP as well as the technologies available for their diagnosis and control are similar. The conditions that favored the eradication of RP are also largely present for PPR. In this work, we outline the evolving strategy for eradication in light of current opportunities and challenges, as well as the lessons from other eradication programs in animal and human health. The global PPR situation and technology for its control are summarized. A strategy based on the lessons from previous eradication efforts that integrate epidemiology, social science, and economics as tools to target and motivate vaccination is summarized. Major aspects of the cost and benefit-cost analysis of the indicated program are presented. The overall undiscounted cost of eradication was estimated as $3.1 billion, and the benefit-cost ratio for the most likely scenario was estimated at 33.8. We close with a discussion of the possible next steps.

AB - Peste des petits ruminants (PPR) is a highly infectious disease of sheep and goats that is caused by PPR virus, a member of the genus Morbillivirus that includes the viruses that cause rinderpest (RP) in cattle. RP was the first animal disease to be globally eradicated in 2011 and is only the second disease, after smallpox, to have ever been eradicated. PPR is one of the principal constraints to small ruminant production in Africa, Asia, and the Middle East. The epidemiology of PPR and RP as well as the technologies available for their diagnosis and control are similar. The conditions that favored the eradication of RP are also largely present for PPR. In this work, we outline the evolving strategy for eradication in light of current opportunities and challenges, as well as the lessons from other eradication programs in animal and human health. The global PPR situation and technology for its control are summarized. A strategy based on the lessons from previous eradication efforts that integrate epidemiology, social science, and economics as tools to target and motivate vaccination is summarized. Major aspects of the cost and benefit-cost analysis of the indicated program are presented. The overall undiscounted cost of eradication was estimated as $3.1 billion, and the benefit-cost ratio for the most likely scenario was estimated at 33.8. We close with a discussion of the possible next steps.

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KW - Cattle/virology

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KW - Enzyme-Linked Immunosorbent Assay

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KW - Goat Diseases/prevention & control

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KW - Viral Vaccines/administration & dosage

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Mariner JC, Jones BA, Rich KM, Thevasagayam S, Anderson J, Jeggo M et al. The opportunity to eradicate peste des petits ruminants. Journal of Immunology. 2016 May 1;196(9):3499-506. https://doi.org/10.4049/jimmunol.1502625