The Post-genomic Era of Trichoderma reesei: What's Next?

Vijai Kumar Gupta*, Andrei Stecca Steindorff, Renato Graciano de Paula, Rafael Silva-Rocha, Astrid R. Mach-Aigner, Robert L. Mach, Roberto N. Silva

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

82 Citations (Scopus)


The ascomycete Trichoderma reesei is one of the most well studied cellulolytic microorganisms. This fungus is widely used in the biotechnology industry, mainly in the production of biofuels. Due to its importance, its genome was sequenced in 2008, opening new avenues to study this microorganism. In this ‘post-genomic’ era, a transcriptomic and proteomic era has emerged. Here, we present an overview of new findings in the gene expression regulation network of T. reesei. We also discuss new rational strategies to obtain mutants that produce hydrolytic enzymes with a higher yield, using metabolic engineering. Finally, we present how synthetic biology strategies can be used to create engineered promoters to efficiently synthesize enzymes for biomass degradation to produce bioethanol.

Original languageEnglish
Pages (from-to)970-982
Number of pages13
JournalTrends in Biotechnology
Issue number12
Early online date6 Jul 2016
Publication statusPrint publication - 1 Dec 2016
Externally publishedYes


  • biofuel
  • cellulases
  • synthetic biology
  • transcriptome
  • Trichoderma reesei


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