The role of micrornas in development of colitis-associated colorectal cancer

Marco Bocchetti, Maria Grazia Ferraro, Filippo Ricciardiello, Alessandro Ottaiano, Amalia Luce, Alessia Maria Cossu, Marianna Scrima, Wing Yan Leung, Marianna Abate, Paola Stiuso, Michele Caraglia, Silvia Zappavigna*, Tung On Yau

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transforma-tion. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.

Original languageEnglish
Article number3967
JournalInternational Journal of Molecular Sciences
Volume22
Issue number8
Early online date12 Apr 2021
DOIs
Publication statusFirst published - 12 Apr 2021
Externally publishedYes

Keywords

  • Biomarkers
  • Colitis-associated colorectal cancer
  • Colorectal cancer
  • Inflammatory bowel disease
  • Mi-croRNA

Fingerprint

Dive into the research topics of 'The role of micrornas in development of colitis-associated colorectal cancer'. Together they form a unique fingerprint.

Cite this