The role of micrornas in development of colitis-associated colorectal cancer

Marco Bocchetti; Maria Grazia Ferraro; Filippo Ricciardiello; Alessandro Ottaiano; Amalia Luce; Alessia Maria Cossu; Marianna Scrima; Wing Yan Leung; Marianna Abate; Paola Stiuso; Michele Caraglia; Silvia Zappavigna; Tung On Yau

doi:10.3390/ijms22083967

The role of micrornas in development of colitis-associated colorectal cancer

Marco Bocchetti, Maria Grazia Ferraro, Filippo Ricciardiello, Alessandro Ottaiano, Amalia Luce, Alessia Maria Cossu, Marianna Scrima, Wing Yan Leung, Marianna Abate, Paola Stiuso, Michele Caraglia, Silvia Zappavigna^*, Tung On Yau^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transforma-tion. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.

Original language	English
Article number	3967
Journal	International Journal of Molecular Sciences
Volume	22
Issue number	8
Early online date	12 Apr 2021
DOIs	https://doi.org/10.3390/ijms22083967
Publication status	First published - 12 Apr 2021
Externally published	Yes

Keywords

Biomarkers
Colitis-associated colorectal cancer
Colorectal cancer
Inflammatory bowel disease
Mi-croRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms22083967Licence: CC BY

Cite this

Bocchetti, M., Ferraro, M. G., Ricciardiello, F., Ottaiano, A., Luce, A., Cossu, A. M., Scrima, M., Leung, W. Y., Abate, M., Stiuso, P., Caraglia, M., Zappavigna, S., & Yau, T. O. (2021). The role of micrornas in development of colitis-associated colorectal cancer. International Journal of Molecular Sciences, 22(8), Article 3967. Advance online publication. https://doi.org/10.3390/ijms22083967

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title = "The role of micrornas in development of colitis-associated colorectal cancer",

abstract = "Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transforma-tion. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes{\textquoteright} expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.",

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author = "Marco Bocchetti and Ferraro, {Maria Grazia} and Filippo Ricciardiello and Alessandro Ottaiano and Amalia Luce and Cossu, {Alessia Maria} and Marianna Scrima and Leung, {Wing Yan} and Marianna Abate and Paola Stiuso and Michele Caraglia and Silvia Zappavigna and Yau, {Tung On}",

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AU - Bocchetti, Marco

AU - Ferraro, Maria Grazia

AU - Ricciardiello, Filippo

AU - Ottaiano, Alessandro

AU - Luce, Amalia

AU - Cossu, Alessia Maria

AU - Scrima, Marianna

AU - Leung, Wing Yan

AU - Abate, Marianna

AU - Stiuso, Paola

AU - Caraglia, Michele

AU - Zappavigna, Silvia

AU - Yau, Tung On

PY - 2021/4/12

Y1 - 2021/4/12

N2 - Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transforma-tion. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.

AB - Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transforma-tion. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment.

KW - Biomarkers

KW - Colitis-associated colorectal cancer

KW - Colorectal cancer

KW - Inflammatory bowel disease

KW - Mi-croRNA

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U2 - 10.3390/ijms22083967

DO - 10.3390/ijms22083967

M3 - Review article

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AN - SCOPUS:85103882260

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JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

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ER -

The role of micrornas in development of colitis-associated colorectal cancer

Abstract

Keywords

UN SDGs

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