The sheep genome illuminates biology of the rumen and lipid metabolism

Yu Jiang; Min Xie; Wenbin Chen; Richard Talbot; Jillian F. Maddox; Thomas Faraut; Chunhua Wu; Donna M. Muzny; Yuxiang Li; Wenguang Zhang; Jo Ann Stanton; Rudiger Brauning; Wesley C. Barris; Thibaut Hourlier; Bronwen L. Aken; Stephen M.J. Searle; David L. Adelson; Chao Bian; Graham R. Cam; Yulin Chen; Shifeng Cheng; Udaya DeSilva; Karen Dixen; Yang Dong; Guangyi Fan; Ian R. Franklin; Shaoyin Fu; Pablo Fuentes-Utrilla; Rui Guan; Margaret A. Highland; Michael E. Holder; Guodong Huang; Aaron B. Ingham; Shalini N. Jhangiani; Divya Kalra; Christie L. Kovar; Sandra L. Lee; Weiqing Liu; Xin Liu; Changxin Lu; Tian Lv; Tittu Mathew; Sean McWilliam; Moira Menzies; Shengkai Pan; David Robelin; Bertrand Servin; David Townley; Wenliang Wang; Bin Wei; Stephen N. White; Xinhua Yang; Chen Ye; Yaojing Yue; Peng Zeng; Qing Zhou; Jacob B. Hansen; Karsten Kristiansen; Richard A. Gibbs; Paul Flicek; Christopher C. Warkup; Huw E. Jones; V. Hutton Oddy; Frank W. Nicholas; John C. McEwan; James W. Kijas; Jun Wang; Kim C. Worley; Alan L. Archibald; Noelle Cockett; Xun Xu; Wen Wang; Brian P. Dalrymple

doi:10.1126/science.1252806

The sheep genome illuminates biology of the rumen and lipid metabolism

Yu Jiang, Min Xie, Wenbin Chen, Richard Talbot, Jillian F. Maddox, Thomas Faraut, Chunhua Wu, Donna M. Muzny, Yuxiang Li, Wenguang Zhang, Jo Ann Stanton, Rudiger Brauning, Wesley C. Barris, Thibaut Hourlier, Bronwen L. Aken, Stephen M.J. Searle, David L. Adelson, Chao Bian, Graham R. Cam, Yulin ChenShifeng Cheng, Udaya DeSilva, Karen Dixen, Yang Dong, Guangyi Fan, Ian R. Franklin, Shaoyin Fu, Pablo Fuentes-Utrilla, Rui Guan, Margaret A. Highland, Michael E. Holder, Guodong Huang, Aaron B. Ingham, Shalini N. Jhangiani, Divya Kalra, Christie L. Kovar, Sandra L. Lee, Weiqing Liu, Xin Liu, Changxin Lu, Tian Lv, Tittu Mathew, Sean McWilliam, Moira Menzies, Shengkai Pan, David Robelin, Bertrand Servin, David Townley, Wenliang Wang, Bin Wei, Stephen N. White, Xinhua Yang, Chen Ye, Yaojing Yue, Peng Zeng, Qing Zhou, Jacob B. Hansen, Karsten Kristiansen, Richard A. Gibbs, Paul Flicek, Christopher C. Warkup, Huw E. Jones, V. Hutton Oddy, Frank W. Nicholas, John C. McEwan, James W. Kijas, Jun Wang, Kim C. Worley^*, Alan L. Archibald, Noelle Cockett, Xun Xu, Wen Wang, Brian P. Dalrymple

^*Corresponding author for this work

Research output: Contribution to journal › Report/ Case Report › peer-review

359 Citations (Scopus)

Abstract

Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

Original language	English
Pages (from-to)	1168-1173
Number of pages	6
Journal	Science
Volume	344
Issue number	6188
DOIs	https://doi.org/10.1126/science.1252806
Publication status	Print publication - 6 Jun 2014
Externally published	Yes

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Jiang, Y., Xie, M., Chen, W., Talbot, R., Maddox, J. F., Faraut, T., Wu, C., Muzny, D. M., Li, Y., Zhang, W., Stanton, J. A., Brauning, R., Barris, W. C., Hourlier, T., Aken, B. L., Searle, S. M. J., Adelson, D. L., Bian, C., Cam, G. R., ... Dalrymple, B. P. (2014). The sheep genome illuminates biology of the rumen and lipid metabolism. Science, 344(6188), 1168-1173. https://doi.org/10.1126/science.1252806

@article{880e88ffb53846b7a9ff1a7b3d29f269,

title = "The sheep genome illuminates biology of the rumen and lipid metabolism",

abstract = "Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.",

author = "Yu Jiang and Min Xie and Wenbin Chen and Richard Talbot and Maddox, {Jillian F.} and Thomas Faraut and Chunhua Wu and Muzny, {Donna M.} and Yuxiang Li and Wenguang Zhang and Stanton, {Jo Ann} and Rudiger Brauning and Barris, {Wesley C.} and Thibaut Hourlier and Aken, {Bronwen L.} and Searle, {Stephen M.J.} and Adelson, {David L.} and Chao Bian and Cam, {Graham R.} and Yulin Chen and Shifeng Cheng and Udaya DeSilva and Karen Dixen and Yang Dong and Guangyi Fan and Franklin, {Ian R.} and Shaoyin Fu and Pablo Fuentes-Utrilla and Rui Guan and Highland, {Margaret A.} and Holder, {Michael E.} and Guodong Huang and Ingham, {Aaron B.} and Jhangiani, {Shalini N.} and Divya Kalra and Kovar, {Christie L.} and Lee, {Sandra L.} and Weiqing Liu and Xin Liu and Changxin Lu and Tian Lv and Tittu Mathew and Sean McWilliam and Moira Menzies and Shengkai Pan and David Robelin and Bertrand Servin and David Townley and Wenliang Wang and Bin Wei and White, {Stephen N.} and Xinhua Yang and Chen Ye and Yaojing Yue and Peng Zeng and Qing Zhou and Hansen, {Jacob B.} and Karsten Kristiansen and Gibbs, {Richard A.} and Paul Flicek and Warkup, {Christopher C.} and Jones, {Huw E.} and Oddy, {V. Hutton} and Nicholas, {Frank W.} and McEwan, {John C.} and Kijas, {James W.} and Jun Wang and Worley, {Kim C.} and Archibald, {Alan L.} and Noelle Cockett and Xun Xu and Wen Wang and Dalrymple, {Brian P.}",

year = "2014",

month = jun,

day = "6",

doi = "10.1126/science.1252806",

language = "English",

volume = "344",

pages = "1168--1173",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6188",

}

Jiang, Y, Xie, M, Chen, W, Talbot, R, Maddox, JF, Faraut, T, Wu, C, Muzny, DM, Li, Y, Zhang, W, Stanton, JA, Brauning, R, Barris, WC, Hourlier, T, Aken, BL, Searle, SMJ, Adelson, DL, Bian, C, Cam, GR, Chen, Y, Cheng, S, DeSilva, U, Dixen, K, Dong, Y, Fan, G, Franklin, IR, Fu, S, Fuentes-Utrilla, P, Guan, R, Highland, MA, Holder, ME, Huang, G, Ingham, AB, Jhangiani, SN, Kalra, D, Kovar, CL, Lee, SL, Liu, W, Liu, X, Lu, C, Lv, T, Mathew, T, McWilliam, S, Menzies, M, Pan, S, Robelin, D, Servin, B, Townley, D, Wang, W, Wei, B, White, SN, Yang, X, Ye, C, Yue, Y, Zeng, P, Zhou, Q, Hansen, JB, Kristiansen, K, Gibbs, RA, Flicek, P, Warkup, CC, Jones, HE, Oddy, VH, Nicholas, FW, McEwan, JC, Kijas, JW, Wang, J, Worley, KC, Archibald, AL, Cockett, N, Xu, X, Wang, W & Dalrymple, BP 2014, 'The sheep genome illuminates biology of the rumen and lipid metabolism', Science, vol. 344, no. 6188, pp. 1168-1173. https://doi.org/10.1126/science.1252806

TY - JOUR

T1 - The sheep genome illuminates biology of the rumen and lipid metabolism

AU - Jiang, Yu

AU - Xie, Min

AU - Chen, Wenbin

AU - Talbot, Richard

AU - Maddox, Jillian F.

AU - Faraut, Thomas

AU - Wu, Chunhua

AU - Muzny, Donna M.

AU - Li, Yuxiang

AU - Zhang, Wenguang

AU - Stanton, Jo Ann

AU - Brauning, Rudiger

AU - Barris, Wesley C.

AU - Hourlier, Thibaut

AU - Aken, Bronwen L.

AU - Searle, Stephen M.J.

AU - Adelson, David L.

AU - Bian, Chao

AU - Cam, Graham R.

AU - Chen, Yulin

AU - Cheng, Shifeng

AU - DeSilva, Udaya

AU - Dixen, Karen

AU - Dong, Yang

AU - Fan, Guangyi

AU - Franklin, Ian R.

AU - Fu, Shaoyin

AU - Fuentes-Utrilla, Pablo

AU - Guan, Rui

AU - Highland, Margaret A.

AU - Holder, Michael E.

AU - Huang, Guodong

AU - Ingham, Aaron B.

AU - Jhangiani, Shalini N.

AU - Kalra, Divya

AU - Kovar, Christie L.

AU - Lee, Sandra L.

AU - Liu, Weiqing

AU - Liu, Xin

AU - Lu, Changxin

AU - Lv, Tian

AU - Mathew, Tittu

AU - McWilliam, Sean

AU - Menzies, Moira

AU - Pan, Shengkai

AU - Robelin, David

AU - Servin, Bertrand

AU - Townley, David

AU - Wang, Wenliang

AU - Wei, Bin

AU - White, Stephen N.

AU - Yang, Xinhua

AU - Ye, Chen

AU - Yue, Yaojing

AU - Zeng, Peng

AU - Zhou, Qing

AU - Hansen, Jacob B.

AU - Kristiansen, Karsten

AU - Gibbs, Richard A.

AU - Flicek, Paul

AU - Warkup, Christopher C.

AU - Jones, Huw E.

AU - Oddy, V. Hutton

AU - Nicholas, Frank W.

AU - McEwan, John C.

AU - Kijas, James W.

AU - Wang, Jun

AU - Worley, Kim C.

AU - Archibald, Alan L.

AU - Cockett, Noelle

AU - Xu, Xun

AU - Wang, Wen

AU - Dalrymple, Brian P.

PY - 2014/6/6

Y1 - 2014/6/6

N2 - Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

AB - Sheep (Ovis aries) are a major source of meat, milk, and fiber in the form of wool and represent a distinct class of animals that have a specialized digestive organ, the rumen, that carries out the initial digestion of plant material. We have developed and analyzed a high-quality reference sheep genome and transcriptomes from 40 different tissues. We identified highly expressed genes encoding keratin cross-linking proteins associated with rumen evolution. We also identified genes involved in lipid metabolism that had been amplified and/or had altered tissue expression patterns. This may be in response to changes in the barrier lipids of the skin, an interaction between lipid metabolism and wool synthesis, and an increased role of volatile fatty acids in ruminants compared with nonruminant animals.

UR - http://www.scopus.com/inward/record.url?scp=84901852226&partnerID=8YFLogxK

U2 - 10.1126/science.1252806

DO - 10.1126/science.1252806

M3 - Report/ Case Report

C2 - 24904168

AN - SCOPUS:84901852226

SN - 0036-8075

VL - 344

SP - 1168

EP - 1173

JO - Science

JF - Science

IS - 6188

ER -

The sheep genome illuminates biology of the rumen and lipid metabolism

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