Transcriptional modulation by VIP: A rational target against inflammatory disease

Hiba Ibrahim, Paul Barrow, Neil Foster*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Vasoactive intestinal peptide (VIP) is a pleiotropic, highly conserved, peptide found in many different biological systems throughout invertebrate phyla. VIP is produced by cells of the immune system but also inhibits many different inflammatory products produced by these immune cells, including cytokines and chemokines. VIP inhibits these immune mediators by affecting transcriptional regulators such as NFκB and activator protein 1 which transcribes genes responsible for the production of inflammatory mediators in response to pathogens or cytokines. In this review, the therapeutic potential of VIP will be discussed in the context of transcriptional regulation of immune cells in in vitro and in vivo animal models.

Original languageEnglish
Pages (from-to)213-222
Number of pages10
JournalClinical Epigenetics
Volume2
Issue number2
DOIs
Publication statusPrint publication - Aug 2011
Externally publishedYes

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