TY - JOUR
T1 - Transcriptional modulation by VIP
T2 - A rational target against inflammatory disease
AU - Ibrahim, Hiba
AU - Barrow, Paul
AU - Foster, Neil
PY - 2011/8
Y1 - 2011/8
N2 - Vasoactive intestinal peptide (VIP) is a pleiotropic, highly conserved, peptide found in many different biological systems throughout invertebrate phyla. VIP is produced by cells of the immune system but also inhibits many different inflammatory products produced by these immune cells, including cytokines and chemokines. VIP inhibits these immune mediators by affecting transcriptional regulators such as NFκB and activator protein 1 which transcribes genes responsible for the production of inflammatory mediators in response to pathogens or cytokines. In this review, the therapeutic potential of VIP will be discussed in the context of transcriptional regulation of immune cells in in vitro and in vivo animal models.
AB - Vasoactive intestinal peptide (VIP) is a pleiotropic, highly conserved, peptide found in many different biological systems throughout invertebrate phyla. VIP is produced by cells of the immune system but also inhibits many different inflammatory products produced by these immune cells, including cytokines and chemokines. VIP inhibits these immune mediators by affecting transcriptional regulators such as NFκB and activator protein 1 which transcribes genes responsible for the production of inflammatory mediators in response to pathogens or cytokines. In this review, the therapeutic potential of VIP will be discussed in the context of transcriptional regulation of immune cells in in vitro and in vivo animal models.
UR - http://www.scopus.com/inward/record.url?scp=84856252333&partnerID=8YFLogxK
U2 - 10.1007/s13148-011-0036-4
DO - 10.1007/s13148-011-0036-4
M3 - Review article
AN - SCOPUS:84856252333
SN - 1868-7075
VL - 2
SP - 213
EP - 222
JO - Clinical Epigenetics
JF - Clinical Epigenetics
IS - 2
ER -