TY - JOUR
T1 - Tuning chitosan's chemical structure for enhanced biological functions
AU - Aghbashlo, Mortaza
AU - Amiri, Hamid
AU - Moosavi Basri, Seyed Masoud
AU - Rastegari, Hajar
AU - Lam, Su Shiung
AU - Pan, Junting
AU - Gupta, Vijai Kumar
AU - Tabatabaei, Meisam
N1 - Publisher Copyright: © 2022 Elsevier Ltd
PY - 2023/6
Y1 - 2023/6
N2 - Chitosan, an amino polysaccharide mostly derived from crustaceans, has been recently highlighted for its biological activities that depend on its molecular weight (MW), degree of deacetylation (DD), and acetylation pattern (AP). More importantly, for some advanced biomaterials, the homogeneity of the chitosan structure is an important factor in determining its biological activity. Here we review emerging enzymes and cell factories, respectively, for in vitro and in vivo preparation of chitosan oligosaccharides (COSs), focusing on advances in the analysis of the AP and structural modification of chitosan to tune its functions. By ‘mapping’ current knowledge on chitosan's in vitro and in vivo activity with its MW and AP, this work could pave the way for future studies in the field.
AB - Chitosan, an amino polysaccharide mostly derived from crustaceans, has been recently highlighted for its biological activities that depend on its molecular weight (MW), degree of deacetylation (DD), and acetylation pattern (AP). More importantly, for some advanced biomaterials, the homogeneity of the chitosan structure is an important factor in determining its biological activity. Here we review emerging enzymes and cell factories, respectively, for in vitro and in vivo preparation of chitosan oligosaccharides (COSs), focusing on advances in the analysis of the AP and structural modification of chitosan to tune its functions. By ‘mapping’ current knowledge on chitosan's in vitro and in vivo activity with its MW and AP, this work could pave the way for future studies in the field.
KW - acetylation pattern
KW - biological activity
KW - chitosan
KW - homogeneity
UR - http://www.scopus.com/inward/record.url?scp=85144260472&partnerID=8YFLogxK
U2 - 10.1016/j.tibtech.2022.11.009
DO - 10.1016/j.tibtech.2022.11.009
M3 - Review article
C2 - 36535818
AN - SCOPUS:85144260472
SN - 0167-7799
VL - 41
SP - 785
EP - 797
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 6
ER -