Tuning chitosan's chemical structure for enhanced biological functions

Mortaza Aghbashlo, Hamid Amiri, Seyed Masoud Moosavi Basri, Hajar Rastegari, Su Shiung Lam, Junting Pan*, Vijai Kumar Gupta, Meisam Tabatabaei

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

19 Citations (Scopus)
11 Downloads (Pure)


Chitosan, an amino polysaccharide mostly derived from crustaceans, has been recently highlighted for its biological activities that depend on its molecular weight (MW), degree of deacetylation (DD), and acetylation pattern (AP). More importantly, for some advanced biomaterials, the homogeneity of the chitosan structure is an important factor in determining its biological activity. Here we review emerging enzymes and cell factories, respectively, for in vitro and in vivo preparation of chitosan oligosaccharides (COSs), focusing on advances in the analysis of the AP and structural modification of chitosan to tune its functions. By ‘mapping’ current knowledge on chitosan's in vitro and in vivo activity with its MW and AP, this work could pave the way for future studies in the field.

Original languageEnglish
Pages (from-to)785-797
Number of pages13
JournalTrends in Biotechnology
Issue number6
Early online date17 Dec 2022
Publication statusPrint publication - Jun 2023

Bibliographical note

Publisher Copyright: © 2022 Elsevier Ltd


  • acetylation pattern
  • biological activity
  • chitosan
  • homogeneity


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