Tuning chitosan's chemical structure for enhanced biological functions

Mortaza Aghbashlo; Hamid Amiri; Seyed Masoud Moosavi Basri; Hajar Rastegari; Su Shiung Lam; Junting Pan; Vijai Kumar Gupta; Meisam Tabatabaei

doi:10.1016/j.tibtech.2022.11.009

Tuning chitosan's chemical structure for enhanced biological functions

Mortaza Aghbashlo, Hamid Amiri, Seyed Masoud Moosavi Basri, Hajar Rastegari, Su Shiung Lam, Junting Pan^*, Vijai Kumar Gupta, Meisam Tabatabaei

^*Corresponding author for this work

Biorefining And Advanced Materials Research Centre

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

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Abstract

Chitosan, an amino polysaccharide mostly derived from crustaceans, has been recently highlighted for its biological activities that depend on its molecular weight (MW), degree of deacetylation (DD), and acetylation pattern (AP). More importantly, for some advanced biomaterials, the homogeneity of the chitosan structure is an important factor in determining its biological activity. Here we review emerging enzymes and cell factories, respectively, for in vitro and in vivo preparation of chitosan oligosaccharides (COSs), focusing on advances in the analysis of the AP and structural modification of chitosan to tune its functions. By ‘mapping’ current knowledge on chitosan's in vitro and in vivo activity with its MW and AP, this work could pave the way for future studies in the field.

Original language	English
Pages (from-to)	785-797
Number of pages	13
Journal	Trends in Biotechnology
Volume	41
Issue number	6
Early online date	17 Dec 2022
DOIs	https://doi.org/10.1016/j.tibtech.2022.11.009
Publication status	Print publication - Jun 2023

Bibliographical note

Keywords

acetylation pattern
biological activity
chitosan
homogeneity

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Manuscript-Clean CopyAccepted author manuscript, 111 KBLicence: CC BY-NC-ND

Cite this

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AU - Aghbashlo, Mortaza

AU - Amiri, Hamid

AU - Moosavi Basri, Seyed Masoud

AU - Rastegari, Hajar

AU - Lam, Su Shiung

AU - Pan, Junting

AU - Gupta, Vijai Kumar

AU - Tabatabaei, Meisam

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Tuning chitosan's chemical structure for enhanced biological functions

Abstract

Bibliographical note

Keywords

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