Value of the Nottingham Histological Grading parameters and Nottingham Prognostic Index in canine mammary carcinoma

M Santos, C Correia-Gomes, R Marcos, A Santos, A De Matos, C Lopes, P Dias-Pereira

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In the past decade, the human Nottingham histological grade (NHG) has been applied to canine mammary carcinomas (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive human breast cancer. The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI. Materials and Methods: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 dogs with CMC. Results: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression. Conclusion: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports.
Original languageEnglish
Pages (from-to)4219 - 4227
Number of pages9
JournalAnticancer Research
Volume35
Issue number7
Publication statusFirst published - 2015

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Canidae
Breast Neoplasms
Survival
Disease Progression
Dogs
Pathology

Bibliographical note

© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved

Keywords

  • Canine mammary tumours
  • Grade
  • Prognosis
  • Survival

Cite this

Santos, M., Correia-Gomes, C., Marcos, R., Santos, A., De Matos, A., Lopes, C., & Dias-Pereira, P. (2015). Value of the Nottingham Histological Grading parameters and Nottingham Prognostic Index in canine mammary carcinoma. Anticancer Research, 35(7), 4219 - 4227.
Santos, M ; Correia-Gomes, C ; Marcos, R ; Santos, A ; De Matos, A ; Lopes, C ; Dias-Pereira, P. / Value of the Nottingham Histological Grading parameters and Nottingham Prognostic Index in canine mammary carcinoma. In: Anticancer Research. 2015 ; Vol. 35, No. 7. pp. 4219 - 4227.
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abstract = "In the past decade, the human Nottingham histological grade (NHG) has been applied to canine mammary carcinomas (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive human breast cancer. The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI. Materials and Methods: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 dogs with CMC. Results: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression. Conclusion: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports.",
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Santos, M, Correia-Gomes, C, Marcos, R, Santos, A, De Matos, A, Lopes, C & Dias-Pereira, P 2015, 'Value of the Nottingham Histological Grading parameters and Nottingham Prognostic Index in canine mammary carcinoma', Anticancer Research, vol. 35, no. 7, pp. 4219 - 4227.

Value of the Nottingham Histological Grading parameters and Nottingham Prognostic Index in canine mammary carcinoma. / Santos, M; Correia-Gomes, C; Marcos, R; Santos, A; De Matos, A; Lopes, C; Dias-Pereira, P.

In: Anticancer Research, Vol. 35, No. 7, 2015, p. 4219 - 4227.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Value of the Nottingham Histological Grading parameters and Nottingham Prognostic Index in canine mammary carcinoma

AU - Santos, M

AU - Correia-Gomes, C

AU - Marcos, R

AU - Santos, A

AU - De Matos, A

AU - Lopes, C

AU - Dias-Pereira, P

N1 - © 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved

PY - 2015

Y1 - 2015

N2 - In the past decade, the human Nottingham histological grade (NHG) has been applied to canine mammary carcinomas (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive human breast cancer. The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI. Materials and Methods: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 dogs with CMC. Results: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression. Conclusion: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports.

AB - In the past decade, the human Nottingham histological grade (NHG) has been applied to canine mammary carcinomas (CMC). The Nottingham Prognostic Index (NPI) enables identification of more aggressive human breast cancer. The prognostic value of grading parameters and NPI has never been detailed in CMC. The aim of the present study was to assess the prognostic value of NHG, its parameters and NPI. Materials and Methods: Univariable and multivariable analyses were used to assess the prognostic value of NHG, its parameters and NPI in a cohort of 59 dogs with CMC. Results: Short disease-free interval and overall survival were associated with higher NHG, particularly of grade III. Only high nuclear pleomorphism score was significantly associated with poor survival. NPI exhibited a strong predictive value for disease progression. Conclusion: NHG, nuclear pleomorphism and NPI have prognostic value in CMC. Nuclear pleomorphism is an independent prognostic factor. Evaluation of nuclear pleomorphism should be included in routine pathology reports.

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JO - Anticancer Research

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Santos M, Correia-Gomes C, Marcos R, Santos A, De Matos A, Lopes C et al. Value of the Nottingham Histological Grading parameters and Nottingham Prognostic Index in canine mammary carcinoma. Anticancer Research. 2015;35(7):4219 - 4227.