Vasoactive intestinal peptide inhibits the production of Salmonella-induced inflammatory cytokines by human monocytes

B. Askar*, P. Barrow, N. Foster

*Corresponding author for this work

Research output: Contribution to conferencePosterpeer-review

Abstract

Systemic salmonella infection is a frequent cause of Gram-negative sepsis. Bacterial lipopolysaccharide in blood triggers immune response by monocytes, which results in overwhelming production of proinflammatory cytokines and pathology in peripheral organs such as the liver, heart and lungs. The mortality rate due to sepsis remains high even after chemotherapeutic clearance of pathogens, due to sustained production of inflammatory mediators. Therefore, anti-inflammatory therapy as an adjunct to antibiotics could reduce the mortality from sepsis.
Original languageEnglish
DOIs
Publication statusFirst published - 3 Dec 2014
Externally publishedYes
EventSepsis 2014 - Paris, France
Duration: 3 Dec 20145 Dec 2014

Conference

ConferenceSepsis 2014
CountryFrance
CityParis
Period3/12/145/12/14

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