Vasoactive intestinal peptide inhibits the production of Salmonella-induced inflammatory cytokines by human monocytes

B. Askar; P. Barrow; N. Foster

doi:10.1186/cc14030

Vasoactive intestinal peptide inhibits the production of Salmonella-induced inflammatory cytokines by human monocytes

B. Askar^*, P. Barrow, N. Foster

^*Corresponding author for this work

Research output: Contribution to conference › Poster › peer-review

Abstract

Systemic salmonella infection is a frequent cause of Gram-negative sepsis. Bacterial lipopolysaccharide in blood triggers immune response by monocytes, which results in overwhelming production of proinflammatory cytokines and pathology in peripheral organs such as the liver, heart and lungs. The mortality rate due to sepsis remains high even after chemotherapeutic clearance of pathogens, due to sustained production of inflammatory mediators. Therefore, anti-inflammatory therapy as an adjunct to antibiotics could reduce the mortality from sepsis.

Original language	English
DOIs	https://doi.org/10.1186/cc14030
Publication status	First published - 3 Dec 2014
Externally published	Yes
Event	Sepsis 2014 - Paris, France Duration: 3 Dec 2014 → 5 Dec 2014

Conference

Conference	Sepsis 2014
Country/Territory	France
City	Paris
Period	3/12/14 → 5/12/14

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10.1186/cc14030

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title = "Vasoactive intestinal peptide inhibits the production of Salmonella-induced inflammatory cytokines by human monocytes",

abstract = "Systemic salmonella infection is a frequent cause of Gram-negative sepsis. Bacterial lipopolysaccharide in blood triggers immune response by monocytes, which results in overwhelming production of proinflammatory cytokines and pathology in peripheral organs such as the liver, heart and lungs. The mortality rate due to sepsis remains high even after chemotherapeutic clearance of pathogens, due to sustained production of inflammatory mediators. Therefore, anti-inflammatory therapy as an adjunct to antibiotics could reduce the mortality from sepsis.",

author = "B. Askar and P. Barrow and N. Foster",

year = "2014",

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doi = "10.1186/cc14030",

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T1 - Vasoactive intestinal peptide inhibits the production of Salmonella-induced inflammatory cytokines by human monocytes

AU - Askar, B.

AU - Barrow, P.

AU - Foster, N.

PY - 2014/12/3

Y1 - 2014/12/3

N2 - Systemic salmonella infection is a frequent cause of Gram-negative sepsis. Bacterial lipopolysaccharide in blood triggers immune response by monocytes, which results in overwhelming production of proinflammatory cytokines and pathology in peripheral organs such as the liver, heart and lungs. The mortality rate due to sepsis remains high even after chemotherapeutic clearance of pathogens, due to sustained production of inflammatory mediators. Therefore, anti-inflammatory therapy as an adjunct to antibiotics could reduce the mortality from sepsis.

AB - Systemic salmonella infection is a frequent cause of Gram-negative sepsis. Bacterial lipopolysaccharide in blood triggers immune response by monocytes, which results in overwhelming production of proinflammatory cytokines and pathology in peripheral organs such as the liver, heart and lungs. The mortality rate due to sepsis remains high even after chemotherapeutic clearance of pathogens, due to sustained production of inflammatory mediators. Therefore, anti-inflammatory therapy as an adjunct to antibiotics could reduce the mortality from sepsis.

UR - http://www.scopus.com/inward/record.url?scp=84928577298&partnerID=8YFLogxK

U2 - 10.1186/cc14030

DO - 10.1186/cc14030

M3 - Poster

AN - SCOPUS:84928577298

T2 - Sepsis 2014

Y2 - 3 December 2014 through 5 December 2014

ER -

Vasoactive intestinal peptide inhibits the production of Salmonella-induced inflammatory cytokines by human monocytes

Abstract

Conference

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