Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1449-1457 |
| Number of pages | 9 |
| Journal | Nature Ecology and Evolution |
| Volume | 2 |
| Issue number | 9 |
| DOIs | |
| Publication status | Print publication - 6 Aug 2018 |
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Keywords
- Agroecology
- Agriculture
- developing world
- Ecological epidemiology
- Economics
Cite this
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Waves of endemic foot-and-mouth disease in eastern Africa suggest feasibility of proactive vaccination approaches. / Casey-Bryars, Miriam; Reeve, Richard; Bastola, Umesh; Knowles, Nick J.; Auty, Harriet; Bachanek-Bankowska, Katarzyna; Fowler, Veronica L.; Fyumagwa, Robert; Kazwala, Rudovick; Kibona, Tito; King, Alasdair; King, Donald P.; Lankester, Felix; Ludi, Anna B.; Lugelo, Ahmed; Maree, Francois F.; Mshanga, Deogratius; Ndhlovu, Gloria; Parekh, Krupali; Paton, David J.; Perry, Brian; Wadsworth, Jemma; Parida, Satya; Haydon, Daniel T.; Marsh, Thomas L.; Cleaveland, Sarah; Lembo, Tiziana.
In: Nature Ecology and Evolution, Vol. 2, No. 9, 06.08.2018, p. 1449-1457.Research output: Contribution to journal › Article
TY - JOUR
T1 - Waves of endemic foot-and-mouth disease in eastern Africa suggest feasibility of proactive vaccination approaches
AU - Casey-Bryars, Miriam
AU - Reeve, Richard
AU - Bastola, Umesh
AU - Knowles, Nick J.
AU - Auty, Harriet
AU - Bachanek-Bankowska, Katarzyna
AU - Fowler, Veronica L.
AU - Fyumagwa, Robert
AU - Kazwala, Rudovick
AU - Kibona, Tito
AU - King, Alasdair
AU - King, Donald P.
AU - Lankester, Felix
AU - Ludi, Anna B.
AU - Lugelo, Ahmed
AU - Maree, Francois F.
AU - Mshanga, Deogratius
AU - Ndhlovu, Gloria
AU - Parekh, Krupali
AU - Paton, David J.
AU - Perry, Brian
AU - Wadsworth, Jemma
AU - Parida, Satya
AU - Haydon, Daniel T.
AU - Marsh, Thomas L.
AU - Cleaveland, Sarah
AU - Lembo, Tiziana
PY - 2018/8/6
Y1 - 2018/8/6
N2 - Livestock production in Africa is key to national economies, food security and rural livelihoods, and > 85% of livestock keepers live in extreme poverty. With poverty elimination central to the Sustainable Development Goals, livestock keepers are therefore critically important. Foot-and-mouth disease is a highly contagious livestock disease widespread in Africa that contributes to this poverty. Despite its US$2.3 billion impact, control of the disease is not prioritized: standard vaccination regimens are too costly, its impact on the poorest is underestimated, and its epidemiology is too weakly understood. Our integrated analysis in Tanzania shows that the disease is of high concern, reduces household budgets for human health, and has major impacts on milk production and draft power for crop production. Critically, foot-and-mouth disease outbreaks in cattle are driven by livestock-related factors with a pattern of changing serotype dominance over time. Contrary to findings in southern Africa, we find no evidence of frequent infection from wildlife, with outbreaks in cattle sweeping slowly across the region through a sequence of dominant serotypes. This regularity suggests that timely identification of the epidemic serotype could allow proactive vaccination ahead of the wave of infection, mitigating impacts, and our preliminary matching work has identified potential vaccine candidates. This strategy is more realistic than wildlife–livestock separation or conventional foot-and-mouth disease vaccination approaches. Overall, we provide strong evidence for the feasibility of coordinated foot-and-mouth disease control as part of livestock development policies in eastern Africa, and our integrated socioeconomic, epidemiological, laboratory and modelling approach provides a framework for the study of other disease systems.
AB - Livestock production in Africa is key to national economies, food security and rural livelihoods, and > 85% of livestock keepers live in extreme poverty. With poverty elimination central to the Sustainable Development Goals, livestock keepers are therefore critically important. Foot-and-mouth disease is a highly contagious livestock disease widespread in Africa that contributes to this poverty. Despite its US$2.3 billion impact, control of the disease is not prioritized: standard vaccination regimens are too costly, its impact on the poorest is underestimated, and its epidemiology is too weakly understood. Our integrated analysis in Tanzania shows that the disease is of high concern, reduces household budgets for human health, and has major impacts on milk production and draft power for crop production. Critically, foot-and-mouth disease outbreaks in cattle are driven by livestock-related factors with a pattern of changing serotype dominance over time. Contrary to findings in southern Africa, we find no evidence of frequent infection from wildlife, with outbreaks in cattle sweeping slowly across the region through a sequence of dominant serotypes. This regularity suggests that timely identification of the epidemic serotype could allow proactive vaccination ahead of the wave of infection, mitigating impacts, and our preliminary matching work has identified potential vaccine candidates. This strategy is more realistic than wildlife–livestock separation or conventional foot-and-mouth disease vaccination approaches. Overall, we provide strong evidence for the feasibility of coordinated foot-and-mouth disease control as part of livestock development policies in eastern Africa, and our integrated socioeconomic, epidemiological, laboratory and modelling approach provides a framework for the study of other disease systems.
KW - Agroecology
KW - Agriculture
KW - developing world
KW - Ecological epidemiology
KW - Economics
U2 - 10.1038/s41559-018-0636-x
DO - 10.1038/s41559-018-0636-x
M3 - Article
C2 - 30082738
VL - 2
SP - 1449
EP - 1457
JO - Nature Ecology and Evolution
JF - Nature Ecology and Evolution
SN - 2397-334X
IS - 9
ER -