TY - JOUR
T1 - Weight loss resistance
T2 - A further consideration for the nutritional management of obese Equidae
AU - Argo, Caroline M.C.G.
AU - Curtis, Gemma C.
AU - Grove-White, Dai
AU - Dugdale, Alexandra H.A.
AU - Barfoot, Clare F.
AU - Harris, Patricia A.
PY - 2012/11/1
Y1 - 2012/11/1
N2 - Evidence-based, weight loss management advice is required to address equine obesity. Changes in body mass (BM), body condition score (BCS), heart (HG) and belly circumference (BG), direct (ultrasonographic) and indirect (D2O dilution, bioelectrical impedance analysis [BIA]) measures of body fat as well as indices of insulin resistance (IR) were monitored in 12 overweight (BCS≥7/9) horses and ponies of mixed breed and gender for 16weeks. Animals were randomly assigned to two groups (Group 1, n=6, BCS 7.6/9±0.6, 489±184.6kg; Group 2, n=6, BCS 8.1/9±0.6, 479±191.5kg). Daily dry matter intake (DMI) was restricted to 1.25% BM as one of two, near-isocaloric (DE ∼0.115MJ/kgBM/day), forage-based diets (Group 1, 0.8% BM chaff-based feed: 0.45% BM hay; Group 2, 1.15% BM hay: 0.1% BM nutrient-balancer).Statistical modelling revealed considerable between-animal heterogeneity in proportional weight losses (0.16-0.55% of Week 1 BM weekly). The magnitude of weight loss resistance (WLR) or sensitivity to dietary restriction was independent of diet or any measured outset variable and was largely (65%) attributed to animal identity. Predicted rates of weight loss decreased over time. BCS and BIA were poor estimates of D2O-derived body fat%. Reciprocal changes in depths of retroperitoneal and subcutaneous adipose tissues were evident. Changes in BG were associated with losses in retroperitoneal fat and BM (r2, 0.67 and 0.79). Indices of IR improved for 9/12 animals by Week 16. For obese animals, weight loss should be initiated by restricting forage DMI to 1.25% BM. Subsequent restriction to 1% BM may be warranted for WLR animals.
AB - Evidence-based, weight loss management advice is required to address equine obesity. Changes in body mass (BM), body condition score (BCS), heart (HG) and belly circumference (BG), direct (ultrasonographic) and indirect (D2O dilution, bioelectrical impedance analysis [BIA]) measures of body fat as well as indices of insulin resistance (IR) were monitored in 12 overweight (BCS≥7/9) horses and ponies of mixed breed and gender for 16weeks. Animals were randomly assigned to two groups (Group 1, n=6, BCS 7.6/9±0.6, 489±184.6kg; Group 2, n=6, BCS 8.1/9±0.6, 479±191.5kg). Daily dry matter intake (DMI) was restricted to 1.25% BM as one of two, near-isocaloric (DE ∼0.115MJ/kgBM/day), forage-based diets (Group 1, 0.8% BM chaff-based feed: 0.45% BM hay; Group 2, 1.15% BM hay: 0.1% BM nutrient-balancer).Statistical modelling revealed considerable between-animal heterogeneity in proportional weight losses (0.16-0.55% of Week 1 BM weekly). The magnitude of weight loss resistance (WLR) or sensitivity to dietary restriction was independent of diet or any measured outset variable and was largely (65%) attributed to animal identity. Predicted rates of weight loss decreased over time. BCS and BIA were poor estimates of D2O-derived body fat%. Reciprocal changes in depths of retroperitoneal and subcutaneous adipose tissues were evident. Changes in BG were associated with losses in retroperitoneal fat and BM (r2, 0.67 and 0.79). Indices of IR improved for 9/12 animals by Week 16. For obese animals, weight loss should be initiated by restricting forage DMI to 1.25% BM. Subsequent restriction to 1% BM may be warranted for WLR animals.
KW - Dietary restriction
KW - Equine obesity
KW - Regional adipose depots
KW - Weight loss
KW - Weight loss resistance
UR - http://www.scopus.com/inward/record.url?scp=84868694873&partnerID=8YFLogxK
U2 - 10.1016/j.tvjl.2012.09.020
DO - 10.1016/j.tvjl.2012.09.020
M3 - Article
C2 - 23117030
AN - SCOPUS:84868694873
SN - 1090-0233
VL - 194
SP - 179
EP - 188
JO - Veterinary Journal
JF - Veterinary Journal
IS - 2
ER -